The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity

BACKGROUND: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) promotes the degradation of LDL receptor in hepatocytes. in vitro studies have proven that insulin increases the expression of PCSK9. Insulin resistance, a common condition in central obesity is characterized by dyslipidemia called At...

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Main Authors: Yusmiati Yusmiati, Burhanuddin Bahar, Andi Wijaya
Format: Article
Language:English
Published: Secretariat of The Indonesian Biomedical Journal 2010-12-01
Series:Indonesian Biomedical Journal
Online Access:http://inabj.org/index.php/ibj/article/view/128
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author Yusmiati Yusmiati
Burhanuddin Bahar
Andi Wijaya
author_facet Yusmiati Yusmiati
Burhanuddin Bahar
Andi Wijaya
author_sort Yusmiati Yusmiati
collection DOAJ
description BACKGROUND: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) promotes the degradation of LDL receptor in hepatocytes. in vitro studies have proven that insulin increases the expression of PCSK9. Insulin resistance, a common condition in central obesity is characterized by dyslipidemia called Atherogenic Lipoprotein Phenotype (ALP). This study aimed to investigate the correlation between insulin resistance (HOMA-IR) and PCSK9, and to analyze whether this condition is related to the development of ALP in central obesity. METHODS: This is an observational study with crosssectional design. The subjects consisted of 62 male adults with central obesity, aged 30-60 years old. ELISA was used to measure plasma PSCK9. RESULTS: The mean plasma PCSK9 concentration of the samples was 283.7 ng/mL. PCSK9 had positive linear correlation with HOMA-IR (r=0.225, p=0.045) and Apo B (r=0.245, p=0.055). After controlling of HOMA-IR, PCSK9 had positive linear correlation with triglycerides (r=0.352, p=0.045). In population with HOMA-IR >2, crosstabs analysis showed that PCSK9 had significant correlation with triglycerides and Apo B with an odd ratio of 6.125 (r=0.376, p=0.037). Triglyceride showed significant negative correlation with HDL cholesterol and ratio of LDL/Apo B, but neither HOMA-IR nor PCSK9 did. CONCLUSIONS: In males with central obesity, PCSK9 is one of the factors mediating the occurence of ALP in insulin resistance. KEYWORDS: PCSK9, insulin resistance, atherogenic lipoprotein phenotype.
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spelling doaj.art-831ada8737044ca99e63f42859fe16b82022-12-21T19:40:31ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792010-12-01231374210.18585/inabj.v2i3.128120The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central ObesityYusmiati Yusmiati0Burhanuddin Bahar1Andi Wijaya2Post Graduate Program in Clinical Biochemistry, Hassanudin University Jl. Perintis Kemerdekaan Km.10, MakassarPost Graduate Program in Clinical Biochemistry, Hassanudin University Jl. Perintis Kemerdekaan Km.10, MakassarPost Graduate Program in Clinical Biochemistry, Hassanudin University Jl. Perintis Kemerdekaan Km.10, MakassarBACKGROUND: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) promotes the degradation of LDL receptor in hepatocytes. in vitro studies have proven that insulin increases the expression of PCSK9. Insulin resistance, a common condition in central obesity is characterized by dyslipidemia called Atherogenic Lipoprotein Phenotype (ALP). This study aimed to investigate the correlation between insulin resistance (HOMA-IR) and PCSK9, and to analyze whether this condition is related to the development of ALP in central obesity. METHODS: This is an observational study with crosssectional design. The subjects consisted of 62 male adults with central obesity, aged 30-60 years old. ELISA was used to measure plasma PSCK9. RESULTS: The mean plasma PCSK9 concentration of the samples was 283.7 ng/mL. PCSK9 had positive linear correlation with HOMA-IR (r=0.225, p=0.045) and Apo B (r=0.245, p=0.055). After controlling of HOMA-IR, PCSK9 had positive linear correlation with triglycerides (r=0.352, p=0.045). In population with HOMA-IR >2, crosstabs analysis showed that PCSK9 had significant correlation with triglycerides and Apo B with an odd ratio of 6.125 (r=0.376, p=0.037). Triglyceride showed significant negative correlation with HDL cholesterol and ratio of LDL/Apo B, but neither HOMA-IR nor PCSK9 did. CONCLUSIONS: In males with central obesity, PCSK9 is one of the factors mediating the occurence of ALP in insulin resistance. KEYWORDS: PCSK9, insulin resistance, atherogenic lipoprotein phenotype.http://inabj.org/index.php/ibj/article/view/128
spellingShingle Yusmiati Yusmiati
Burhanuddin Bahar
Andi Wijaya
The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity
Indonesian Biomedical Journal
title The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity
title_full The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity
title_fullStr The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity
title_full_unstemmed The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity
title_short The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity
title_sort correlation between proprotein convertase subtilisin kexin type 9 pcsk9 and insulin resistance and the components of atherogenic lipoprotein phenotype in males with central obesity
url http://inabj.org/index.php/ibj/article/view/128
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