The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats
The ongoing work aims to compare the effect of extraneural and intraneural injection of therapeutic doses of meloxicam and diclofenac sodium on the sciatic nerve of rats. Six groups of adult albino rats were used with five animals per group. Control group (A), group (B), and group (C) received a sin...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2022-06-01
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| Series: | Iraqi Journal of Veterinary Sciences |
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| Online Access: | https://vetmedmosul.com/article_173301_5b0a3ff68857bcff899e4d4dcfb26224.pdf |
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| author | Mustafa M. Altaee Ahmed H. Qassim |
| author_facet | Mustafa M. Altaee Ahmed H. Qassim |
| author_sort | Mustafa M. Altaee |
| collection | DOAJ |
| description | The ongoing work aims to compare the effect of extraneural and intraneural injection of therapeutic doses of meloxicam and diclofenac sodium on the sciatic nerve of rats. Six groups of adult albino rats were used with five animals per group. Control group (A), group (B), and group (C) received a single extraneural injection of normal saline (NS) 0.25 ml/kg/rat, meloxicam (M) 0.11 mg/kg/0.25ml/rat and diclofenac sodium (V) 1.1 mg/kg/0.25ml/rat respectively. In contrast, control group (D), group (E), and group (F) received a single intraneural injection of the same doses of normal saline, meloxicam, and diclofenac sodium, respectively. Histological evaluation reveals an increased thickening of epineurium, dilatation, congestion of epineurial blood vessels, intrafascicular edema, axonal degeneration, myelin degeneration, and vacuolization in group (C) which was higher than those in the group (B). These changes were also greater in group (F) compared to groups (D) and (E). The histopathological changes of the sciatic nerve were greatest in the case of intraneural injection of saline, meloxicam, and diclofenac sodium, which means that the damaging effect of intraneural injection of the drug was greater than the extraneural injection of the same drug. It is concluded that extraneural and intraneural injections of therapeutic doses of meloxicam cause less damage to the sciatic nerve compared to diclofenac sodium. Thus it is considered to be more secure than diclofenac sodium after intramuscular injection. Sciatic nerve injury can occur following intramuscular injection into the gluteal region, particularly if the needle hits the nerve. |
| first_indexed | 2024-04-12T12:59:28Z |
| format | Article |
| id | doaj.art-831ba32fc04c48918211aacbd6c129c6 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-04-12T12:59:28Z |
| publishDate | 2022-06-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-831ba32fc04c48918211aacbd6c129c62022-12-22T03:32:13ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552022-06-0136369970710.33899/ijvs.2021.131529.1961173301The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of ratsMustafa M. Altaee0Ahmed H. Qassim1Department of Anatomy, Histology and Embryology, College of Medicine, University of Mosul, Mosul, IraqDepartment of Anatomy, College of Medicine, University of Mosul, Mosul , IraqThe ongoing work aims to compare the effect of extraneural and intraneural injection of therapeutic doses of meloxicam and diclofenac sodium on the sciatic nerve of rats. Six groups of adult albino rats were used with five animals per group. Control group (A), group (B), and group (C) received a single extraneural injection of normal saline (NS) 0.25 ml/kg/rat, meloxicam (M) 0.11 mg/kg/0.25ml/rat and diclofenac sodium (V) 1.1 mg/kg/0.25ml/rat respectively. In contrast, control group (D), group (E), and group (F) received a single intraneural injection of the same doses of normal saline, meloxicam, and diclofenac sodium, respectively. Histological evaluation reveals an increased thickening of epineurium, dilatation, congestion of epineurial blood vessels, intrafascicular edema, axonal degeneration, myelin degeneration, and vacuolization in group (C) which was higher than those in the group (B). These changes were also greater in group (F) compared to groups (D) and (E). The histopathological changes of the sciatic nerve were greatest in the case of intraneural injection of saline, meloxicam, and diclofenac sodium, which means that the damaging effect of intraneural injection of the drug was greater than the extraneural injection of the same drug. It is concluded that extraneural and intraneural injections of therapeutic doses of meloxicam cause less damage to the sciatic nerve compared to diclofenac sodium. Thus it is considered to be more secure than diclofenac sodium after intramuscular injection. Sciatic nerve injury can occur following intramuscular injection into the gluteal region, particularly if the needle hits the nerve.https://vetmedmosul.com/article_173301_5b0a3ff68857bcff899e4d4dcfb26224.pdfaxonal degenerationdiclofenac sodiumintraneural injectionmeloxicamsciatic nerve |
| spellingShingle | Mustafa M. Altaee Ahmed H. Qassim The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats Iraqi Journal of Veterinary Sciences axonal degeneration diclofenac sodium intraneural injection meloxicam sciatic nerve |
| title | The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats |
| title_full | The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats |
| title_fullStr | The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats |
| title_full_unstemmed | The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats |
| title_short | The histological effect of the injection of nonsteroidal anti-inflammatory drugs on sciatic nerve of rats |
| title_sort | histological effect of the injection of nonsteroidal anti inflammatory drugs on sciatic nerve of rats |
| topic | axonal degeneration diclofenac sodium intraneural injection meloxicam sciatic nerve |
| url | https://vetmedmosul.com/article_173301_5b0a3ff68857bcff899e4d4dcfb26224.pdf |
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