Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer
ABSTRACTCandida albicans is one of the most common opportunistic fungi in cancer patients. This study explored the influence of C. albicans on gut microbiota in oral tumour-bearing mice by means of 16S rRNA sequencing and ITS sequencing. It was found that C. albicans infection induced the decrease o...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-01-01
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| Series: | Mycology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21501203.2023.2256761 |
| _version_ | 1797242555904032768 |
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| author | Xu Wang Shuangshaung Wu Linman Li Zhimin Yan |
| author_facet | Xu Wang Shuangshaung Wu Linman Li Zhimin Yan |
| author_sort | Xu Wang |
| collection | DOAJ |
| description | ABSTRACTCandida albicans is one of the most common opportunistic fungi in cancer patients. This study explored the influence of C. albicans on gut microbiota in oral tumour-bearing mice by means of 16S rRNA sequencing and ITS sequencing. It was found that C. albicans infection induced the decrease of alpha diversity of bacteria and fungi in the gut microbiome. For the bacteria, C. albicans caused the reduction of Ralstonia, Alistipes, Clostridia UCG-014, Ruminococcus, and Lachnospiraceae NK4A136 group. For the fungi, C. albicans inhibited the growth of other fungi including Aspergillus, Cladosporium, and Bipolaris. The neutralisation of γδT cells partly alleviated the out-of-balance of Firmicutes/Bacteroidota (F/B) ratio in the gut caused by C. albicans infection. However, γδT cell neutralisation boosted the overgrowth of C. albicans. Additionally, IL-17A neutralisation aggravated the microbial dysbiosis of bacteria and fungi caused by C. albicans infection. Further analysis indicated that C. albicans overgrowth might influence the correlations between fungal and bacterial kingdoms. In conclusion, C. albicans infection disturbed the gut microbiota of both bacteria and fungi in oral tumour-bearing mice, which may be associated with the intestinal immune components including γδT cells and IL-17A. |
| first_indexed | 2024-04-24T18:41:05Z |
| format | Article |
| id | doaj.art-831d4574474746439d818443b9551576 |
| institution | Directory Open Access Journal |
| issn | 2150-1203 2150-1211 |
| language | English |
| last_indexed | 2024-04-24T18:41:05Z |
| publishDate | 2024-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycology |
| spelling | doaj.art-831d4574474746439d818443b95515762024-03-27T12:44:51ZengTaylor & Francis GroupMycology2150-12032150-12112024-01-01151576910.1080/21501203.2023.2256761Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancerXu Wang0Shuangshaung Wu1Linman Li2Zhimin Yan3Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, ChinaABSTRACTCandida albicans is one of the most common opportunistic fungi in cancer patients. This study explored the influence of C. albicans on gut microbiota in oral tumour-bearing mice by means of 16S rRNA sequencing and ITS sequencing. It was found that C. albicans infection induced the decrease of alpha diversity of bacteria and fungi in the gut microbiome. For the bacteria, C. albicans caused the reduction of Ralstonia, Alistipes, Clostridia UCG-014, Ruminococcus, and Lachnospiraceae NK4A136 group. For the fungi, C. albicans inhibited the growth of other fungi including Aspergillus, Cladosporium, and Bipolaris. The neutralisation of γδT cells partly alleviated the out-of-balance of Firmicutes/Bacteroidota (F/B) ratio in the gut caused by C. albicans infection. However, γδT cell neutralisation boosted the overgrowth of C. albicans. Additionally, IL-17A neutralisation aggravated the microbial dysbiosis of bacteria and fungi caused by C. albicans infection. Further analysis indicated that C. albicans overgrowth might influence the correlations between fungal and bacterial kingdoms. In conclusion, C. albicans infection disturbed the gut microbiota of both bacteria and fungi in oral tumour-bearing mice, which may be associated with the intestinal immune components including γδT cells and IL-17A.https://www.tandfonline.com/doi/10.1080/21501203.2023.2256761Candida albicansgut microbiotaoral cancerγδt cellsIL-17A |
| spellingShingle | Xu Wang Shuangshaung Wu Linman Li Zhimin Yan Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer Mycology Candida albicans gut microbiota oral cancer γδt cells IL-17A |
| title | Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer |
| title_full | Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer |
| title_fullStr | Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer |
| title_full_unstemmed | Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer |
| title_short | Candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer |
| title_sort | candida albicans overgrowth disrupts the gut microbiota in mice bearing oral cancer |
| topic | Candida albicans gut microbiota oral cancer γδt cells IL-17A |
| url | https://www.tandfonline.com/doi/10.1080/21501203.2023.2256761 |
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