Nitrofurans' residues in food of animal origin
Nitrofurans are synthetic broad-spectrum antimicobial agents that are often used in commercial animal production because of their excellent antibacterial and pharmacokinetic properties. However, nitrofurans and their metabolites have been shown to have potentially carcinogenic and mutagenic...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, Belgrade
2011-01-01
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| Series: | Veterinarski Glasnik |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0350-2457/2011/0350-24571104215S.pdf |
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| author | Smajlović Ahmed Mujezinović Indira Ćupić Vitomir Muminović Mehmed |
| author_facet | Smajlović Ahmed Mujezinović Indira Ćupić Vitomir Muminović Mehmed |
| author_sort | Smajlović Ahmed |
| collection | DOAJ |
| description | Nitrofurans are synthetic broad-spectrum antimicobial agents that are often
used in commercial animal production because of their excellent antibacterial
and pharmacokinetic properties. However, nitrofurans and their metabolites
have been shown to have potentially carcinogenic and mutagenic
characteristics which has led to a ban on the use of nitrofurans in
preventive and therapeutic treatment of animals used for food production.
Metabolites of nitrofurans that can be determined after their application
are: a metabolite of furazolidone, furaltadone metabolite, a metabolite of
nitrofurantoin and nitrofurazone metabolite. The presence of residues of
nitrofuran antibiotics in meat, fish and shrimps, and milk and eggs
originating from countries outside the European Union is monitored and
recorded by the RASFF system of the European Union. Furthermore, since
nitrofurans are used in some countries as prophylactic agents and growth
promoters, it is necessary to carry out constant control of various types of
food of animal origin, in order to reduce to the minimum potential
carcinogenic and mutagenic effects of these supstances for the health of
consumers. In Bosnia and Herzegovina, there is no permanent control of
nitrofurans in food of animal origin. The provisions of the „Regulation on
the maximum allowable amounts of veterinary drugs and pesticides in products
of animal origin", published in the Official Gazette of Bosnia and
Herzegovina state the prohibiting of the use of certain veterinary drugs in
animals intended for human consumption, including nitrofurans. The European
Union has established the minimum required limit (MRLP) for performance which
is 1 μg/kg of nitrofurans for edible tissues of animal origin. Taking all
this into account, methods for nitrofurans detection should be accreditated
and validated, both for screening and confirmatory methods, and further
research into the presence of nitrofurans in food of animal origin in Bosnia
and Herzegovina should be performed. |
| first_indexed | 2024-12-24T04:25:28Z |
| format | Article |
| id | doaj.art-831d745b0e32436da9a5e9be9ae8e9ef |
| institution | Directory Open Access Journal |
| issn | 0350-2457 2406-0771 |
| language | English |
| last_indexed | 2024-12-24T04:25:28Z |
| publishDate | 2011-01-01 |
| publisher | Faculty of Veterinary Medicine, Belgrade |
| record_format | Article |
| series | Veterinarski Glasnik |
| spelling | doaj.art-831d745b0e32436da9a5e9be9ae8e9ef2022-12-21T17:15:40ZengFaculty of Veterinary Medicine, BelgradeVeterinarski Glasnik0350-24572406-07712011-01-01653-421522210.2298/VETGL1104215S0350-24571104215SNitrofurans' residues in food of animal originSmajlović Ahmed0Mujezinović Indira1Ćupić Vitomir2Muminović Mehmed3Katedra za farmakologiju i toksikologiju, Fakultet veterinarske medicine, Univerzitet u Sarajevu, Bosna i HercegovinaKatedra za farmakologiju i toksikologiju, Fakultet veterinarske medicine, Univerzitet u Sarajevu, Bosna i HercegovinaKatedra za farmakologiju i toksikologiju, Fakultet veterinarske medicine, BeogradKatedra za farmakologiju i toksikologiju, Fakultet veterinarske medicine, Univerzitet u Sarajevu, Bosna i HercegovinaNitrofurans are synthetic broad-spectrum antimicobial agents that are often used in commercial animal production because of their excellent antibacterial and pharmacokinetic properties. However, nitrofurans and their metabolites have been shown to have potentially carcinogenic and mutagenic characteristics which has led to a ban on the use of nitrofurans in preventive and therapeutic treatment of animals used for food production. Metabolites of nitrofurans that can be determined after their application are: a metabolite of furazolidone, furaltadone metabolite, a metabolite of nitrofurantoin and nitrofurazone metabolite. The presence of residues of nitrofuran antibiotics in meat, fish and shrimps, and milk and eggs originating from countries outside the European Union is monitored and recorded by the RASFF system of the European Union. Furthermore, since nitrofurans are used in some countries as prophylactic agents and growth promoters, it is necessary to carry out constant control of various types of food of animal origin, in order to reduce to the minimum potential carcinogenic and mutagenic effects of these supstances for the health of consumers. In Bosnia and Herzegovina, there is no permanent control of nitrofurans in food of animal origin. The provisions of the „Regulation on the maximum allowable amounts of veterinary drugs and pesticides in products of animal origin", published in the Official Gazette of Bosnia and Herzegovina state the prohibiting of the use of certain veterinary drugs in animals intended for human consumption, including nitrofurans. The European Union has established the minimum required limit (MRLP) for performance which is 1 μg/kg of nitrofurans for edible tissues of animal origin. Taking all this into account, methods for nitrofurans detection should be accreditated and validated, both for screening and confirmatory methods, and further research into the presence of nitrofurans in food of animal origin in Bosnia and Herzegovina should be performed.http://www.doiserbia.nb.rs/img/doi/0350-2457/2011/0350-24571104215S.pdfnitrofuransRASFF systemMRPLscreening and confirmative methods |
| spellingShingle | Smajlović Ahmed Mujezinović Indira Ćupić Vitomir Muminović Mehmed Nitrofurans' residues in food of animal origin Veterinarski Glasnik nitrofurans RASFF system MRPL screening and confirmative methods |
| title | Nitrofurans' residues in food of animal origin |
| title_full | Nitrofurans' residues in food of animal origin |
| title_fullStr | Nitrofurans' residues in food of animal origin |
| title_full_unstemmed | Nitrofurans' residues in food of animal origin |
| title_short | Nitrofurans' residues in food of animal origin |
| title_sort | nitrofurans residues in food of animal origin |
| topic | nitrofurans RASFF system MRPL screening and confirmative methods |
| url | http://www.doiserbia.nb.rs/img/doi/0350-2457/2011/0350-24571104215S.pdf |
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