Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population
BackgroundHypertension alone is a poor predictor of the individual risk of cardiovascular disease. Hereditary factors of which hypertension is merely a marker may explain why some hypertensive individuals appear more susceptible to cardiovascular disease, and why some ethnicities have more often see...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-12-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.004260 |
| _version_ | 1828315549606608896 |
|---|---|
| author | Luca Valerio Ron J. Peters Aeilko H. Zwinderman Sara‐Joan Pinto‐Sietsma |
| author_facet | Luca Valerio Ron J. Peters Aeilko H. Zwinderman Sara‐Joan Pinto‐Sietsma |
| author_sort | Luca Valerio |
| collection | DOAJ |
| description | BackgroundHypertension alone is a poor predictor of the individual risk of cardiovascular disease. Hereditary factors of which hypertension is merely a marker may explain why some hypertensive individuals appear more susceptible to cardiovascular disease, and why some ethnicities have more often seemingly hypertension‐related cardiovascular disease than others. We hypothesize that, in hypertensive individuals, a positive family history of cardiovascular disease identifies a high‐risk subpopulation. Methods and ResultsHealthy Life in Urban Settings (HELIUS) is a cohort study among participants of Dutch, South‐Asian Surinamese, African Surinamese, Ghanaian, Turkish, and Moroccan origin aged 70 years and younger. In participants with hypertension (n=6467), we used logistic regression to assess the association of family history of cardiovascular disease with prevalent stroke and nonstroke cardiovascular disease, adjusting for sex, age, education, and smoking. To detect ethnic differences, we tested for interaction between family history and ethnicity and stratified the analysis by ethnicity. A positive family history was associated with a higher prevalence of nonstroke cardiovascular disease (odds ratio [OR], 2.05; 95% CI, 1.65–2.54) and stroke (OR, 1.62; 95% CI, 1.19–2.20). The strongest association of family history with nonstroke cardiovascular disease was found among the Dutch (OR, 2.47; 95% CI, 1.37–4.44) and with stroke among the African Surinamese (OR, 2.17; 95% CI, 1.32–3.57). The interaction between family history and African Surinamese origin for stroke was statistically significant. ConclusionsIn multiethnic populations of hypertensive patients, a positive family history of cardiovascular disease may be used clinically to identify individuals at high risk for nonstroke cardiovascular disease regardless of ethnic origin and African Surinamese individuals at high risk for stroke. |
| first_indexed | 2024-04-13T17:02:21Z |
| format | Article |
| id | doaj.art-831f8ab69a77430d830cd8291d91f4cc |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T17:02:21Z |
| publishDate | 2016-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-831f8ab69a77430d830cd8291d91f4cc2022-12-22T02:38:37ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-12-0151210.1161/JAHA.116.004260Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic PopulationLuca Valerio0Ron J. Peters1Aeilko H. Zwinderman2Sara‐Joan Pinto‐Sietsma3Department of Public Health, University of Amsterdam Academic Medical Center, Amsterdam, the NetherlandsDepartment of Cardiology, University of Amsterdam Academic Medical Center, Amsterdam, the NetherlandsDepartment of Clinical Epidemiology and Biostatistics, University of Amsterdam Academic Medical Center, Amsterdam, the NetherlandsDepartment of Vascular Medicine, University of Amsterdam Academic Medical Center, Amsterdam, the NetherlandsBackgroundHypertension alone is a poor predictor of the individual risk of cardiovascular disease. Hereditary factors of which hypertension is merely a marker may explain why some hypertensive individuals appear more susceptible to cardiovascular disease, and why some ethnicities have more often seemingly hypertension‐related cardiovascular disease than others. We hypothesize that, in hypertensive individuals, a positive family history of cardiovascular disease identifies a high‐risk subpopulation. Methods and ResultsHealthy Life in Urban Settings (HELIUS) is a cohort study among participants of Dutch, South‐Asian Surinamese, African Surinamese, Ghanaian, Turkish, and Moroccan origin aged 70 years and younger. In participants with hypertension (n=6467), we used logistic regression to assess the association of family history of cardiovascular disease with prevalent stroke and nonstroke cardiovascular disease, adjusting for sex, age, education, and smoking. To detect ethnic differences, we tested for interaction between family history and ethnicity and stratified the analysis by ethnicity. A positive family history was associated with a higher prevalence of nonstroke cardiovascular disease (odds ratio [OR], 2.05; 95% CI, 1.65–2.54) and stroke (OR, 1.62; 95% CI, 1.19–2.20). The strongest association of family history with nonstroke cardiovascular disease was found among the Dutch (OR, 2.47; 95% CI, 1.37–4.44) and with stroke among the African Surinamese (OR, 2.17; 95% CI, 1.32–3.57). The interaction between family history and African Surinamese origin for stroke was statistically significant. ConclusionsIn multiethnic populations of hypertensive patients, a positive family history of cardiovascular disease may be used clinically to identify individuals at high risk for nonstroke cardiovascular disease regardless of ethnic origin and African Surinamese individuals at high risk for stroke.https://www.ahajournals.org/doi/10.1161/JAHA.116.004260cardiovascular diseasescerebrovascular disease/strokeHELIUS studyhypertensionrace and ethnicity |
| spellingShingle | Luca Valerio Ron J. Peters Aeilko H. Zwinderman Sara‐Joan Pinto‐Sietsma Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular diseases cerebrovascular disease/stroke HELIUS study hypertension race and ethnicity |
| title | Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population |
| title_full | Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population |
| title_fullStr | Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population |
| title_full_unstemmed | Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population |
| title_short | Association of Family History With Cardiovascular Disease in Hypertensive Individuals in a Multiethnic Population |
| title_sort | association of family history with cardiovascular disease in hypertensive individuals in a multiethnic population |
| topic | cardiovascular diseases cerebrovascular disease/stroke HELIUS study hypertension race and ethnicity |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.004260 |
| work_keys_str_mv | AT lucavalerio associationoffamilyhistorywithcardiovasculardiseaseinhypertensiveindividualsinamultiethnicpopulation AT ronjpeters associationoffamilyhistorywithcardiovasculardiseaseinhypertensiveindividualsinamultiethnicpopulation AT aeilkohzwinderman associationoffamilyhistorywithcardiovasculardiseaseinhypertensiveindividualsinamultiethnicpopulation AT sarajoanpintosietsma associationoffamilyhistorywithcardiovasculardiseaseinhypertensiveindividualsinamultiethnicpopulation |