Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection
Early detection of liver diseases holds paramount importance in optimizing treatment outcomes and prognosis, thereby significantly enhancing the likelihood of recovery while mitigating the risk of progression to liver cancer. Liver diseases encompass a spectrum of conditions, each potentially manife...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1392857/full |
| _version_ | 1797201257832644608 |
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| author | Shifeng Liu Yatong Yin Shihai Liu Congxiao Wang Wenshe Sun Xiaokun Hu |
| author_facet | Shifeng Liu Yatong Yin Shihai Liu Congxiao Wang Wenshe Sun Xiaokun Hu |
| author_sort | Shifeng Liu |
| collection | DOAJ |
| description | Early detection of liver diseases holds paramount importance in optimizing treatment outcomes and prognosis, thereby significantly enhancing the likelihood of recovery while mitigating the risk of progression to liver cancer. Liver diseases encompass a spectrum of conditions, each potentially manifesting distinct enzymatic profiles. Monitoring these enzymes in situ facilitates timely intervention and therapeutic management. In recent years, the field of biosensor technology has witnessed remarkable advancement, owing to strides in biomedicine and computational sciences. Biosensors have garnered widespread utility across medical and biological domains, spanning the detection of disease biomarkers, drug release tracking, ion imaging, and fluorescence imaging within living organisms. These applications have markedly enhanced imaging resolution and have the potential to refine disease diagnosis accuracy for clinicians. A pivotal aspect in the successful application of this technology lies in the construction of fluorescence probes adept at swiftly and selectively identifying target enzymes by amalgamating liver disease enzymes with fluorescence probe technology. However, research in this niche area remains relatively scarce. Building upon this foundational understanding, the present review delineates the utilization of biosensors in the early diagnosis of liver disease. Serving as a theoretical framework, this review envisages the development of high-performance biosensors tailored for the early detection of liver cancer. Furthermore, it offers insights into the potential of biosensor technology to progress and broaden its practical applications, thus contributing to the advancement of diagnostic methodologies in liver disease management. |
| first_indexed | 2024-04-24T07:44:40Z |
| format | Article |
| id | doaj.art-831fbb0b3a5f4898a990e1285fe9c6c9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-24T07:44:40Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-831fbb0b3a5f4898a990e1285fe9c6c92024-04-19T04:41:05ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-04-011210.3389/fbioe.2024.13928571392857Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detectionShifeng Liu0Yatong Yin1Shihai Liu2Congxiao Wang3Wenshe Sun4Xiaokun Hu5Department of the Interventional Medical Center, the Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao Maternal and Child Health and Family Planning Service Center, Qingdao, ChinaMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of the Interventional Medical Center, the Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao Cancer Institute, Qingdao University, Qingdao, ChinaDepartment of the Interventional Medical Center, the Affiliated Hospital of Qingdao University, Qingdao, ChinaEarly detection of liver diseases holds paramount importance in optimizing treatment outcomes and prognosis, thereby significantly enhancing the likelihood of recovery while mitigating the risk of progression to liver cancer. Liver diseases encompass a spectrum of conditions, each potentially manifesting distinct enzymatic profiles. Monitoring these enzymes in situ facilitates timely intervention and therapeutic management. In recent years, the field of biosensor technology has witnessed remarkable advancement, owing to strides in biomedicine and computational sciences. Biosensors have garnered widespread utility across medical and biological domains, spanning the detection of disease biomarkers, drug release tracking, ion imaging, and fluorescence imaging within living organisms. These applications have markedly enhanced imaging resolution and have the potential to refine disease diagnosis accuracy for clinicians. A pivotal aspect in the successful application of this technology lies in the construction of fluorescence probes adept at swiftly and selectively identifying target enzymes by amalgamating liver disease enzymes with fluorescence probe technology. However, research in this niche area remains relatively scarce. Building upon this foundational understanding, the present review delineates the utilization of biosensors in the early diagnosis of liver disease. Serving as a theoretical framework, this review envisages the development of high-performance biosensors tailored for the early detection of liver cancer. Furthermore, it offers insights into the potential of biosensor technology to progress and broaden its practical applications, thus contributing to the advancement of diagnostic methodologies in liver disease management.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1392857/fullliver diseaseenzymesbiosensorsearly diagnosisliver cancer |
| spellingShingle | Shifeng Liu Yatong Yin Shihai Liu Congxiao Wang Wenshe Sun Xiaokun Hu Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection Frontiers in Bioengineering and Biotechnology liver disease enzymes biosensors early diagnosis liver cancer |
| title | Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection |
| title_full | Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection |
| title_fullStr | Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection |
| title_full_unstemmed | Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection |
| title_short | Shining a light on liver health: advancements in fluorescence-enhanced enzyme biosensors for early disease detection |
| title_sort | shining a light on liver health advancements in fluorescence enhanced enzyme biosensors for early disease detection |
| topic | liver disease enzymes biosensors early diagnosis liver cancer |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1392857/full |
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