Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system

Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system

Human induced pluripotent stem cells (iPSCs) have great promise in regenerative medicine. However, several limitations, including immune-incompatibility, have raised concerns regarding their clinical application. Recent studies have shown that human iPSCs and their derivatives lose their immunogenic...

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Bibliographic Details
Main Authors: Elena Romano, Piera Trionfini, Roberta Giampietro, Ariela Benigni, Susanna Tomasoni
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350612100427X

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