Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke
Objective To investigate longitudinal changes in language function in left-hemispheric ischemic stroke patients as well as factors that influence language recovery until 1 year after stroke onset. Methods We analyzed data from 235 patients with first-ever left-hemispheric ischemic stroke. All patien...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Academy of Rehabilitation Medicine
2019-12-01
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| Series: | Annals of Rehabilitation Medicine |
| Subjects: | |
| Online Access: | http://www.e-arm.org/upload/pdf/arm-2019-43-6-625.pdf |
| _version_ | 1827884483641081856 |
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| author | Kyung Ah Kim Jung Soo Lee Won Hyuk Chang Deog Young Kim Yong-Il Shin Soo-Yeon Kim Young Taek Kim Sung Hyun Kang Ji Yoo Choi Yun-Hee Kim |
| author_facet | Kyung Ah Kim Jung Soo Lee Won Hyuk Chang Deog Young Kim Yong-Il Shin Soo-Yeon Kim Young Taek Kim Sung Hyun Kang Ji Yoo Choi Yun-Hee Kim |
| author_sort | Kyung Ah Kim |
| collection | DOAJ |
| description | Objective To investigate longitudinal changes in language function in left-hemispheric ischemic stroke patients as well as factors that influence language recovery until 1 year after stroke onset. Methods We analyzed data from 235 patients with first-ever left-hemispheric ischemic stroke. All patients completed the Korean version of the Frenchay Aphasia Screening Test (K-FAST) at 7 days (T1), 3 months (T2), 6 months (T3), and 1 year (T4) after stroke onset. Repeated measures analysis of variance (ANOVA) was used to investigate changes in language function between time points. Subgroup analysis was performed according to the K-FAST scores at T1. Stroke lesion volume was assessed using diffusion tensor images, and involvement of language-related brain regions was examined. Multiple regression analysis was used to analyze factors influencing improvement of K-FAST score. Results The K-FAST scores at T1, T2, T3, and T4 differed significantly (p<0.05). In the subgroup analysis, only the severe group showed continuous significant improvement by 1 year. Factors that negatively influenced improvement of language function were the age at onset, initial National Institutes of Health Stroke Scale (NIHSS) score, and initial K-FAST score, whereas education level and stroke lesion volume positively affected recovery. Involvement of language-related brain regions did not significantly influence long-term language recovery after ischemic stroke. Conclusion Recovery of language function varied according to the severity of the initial language deficit. The age at stroke onset, education level, initial severity of aphasia, initial NIHSS score, and total stroke lesion volume were found to be important factors for recovery of language function. |
| first_indexed | 2024-03-12T19:29:44Z |
| format | Article |
| id | doaj.art-83207931d72643a9a23461c905908b6e |
| institution | Directory Open Access Journal |
| issn | 2234-0645 2234-0653 |
| language | English |
| last_indexed | 2024-03-12T19:29:44Z |
| publishDate | 2019-12-01 |
| publisher | Korean Academy of Rehabilitation Medicine |
| record_format | Article |
| series | Annals of Rehabilitation Medicine |
| spelling | doaj.art-83207931d72643a9a23461c905908b6e2023-08-02T04:41:38ZengKorean Academy of Rehabilitation MedicineAnnals of Rehabilitation Medicine2234-06452234-06532019-12-0143662563410.5535/arm.2019.43.6.6254125Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic StrokeKyung Ah Kim0Jung Soo Lee1Won Hyuk Chang2Deog Young Kim3Yong-Il Shin4Soo-Yeon Kim5Young Taek Kim6Sung Hyun Kang7Ji Yoo Choi8Yun-Hee Kim9 Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Rehabilitation Medicine and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Korea Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Busan, Korea Division of Chronic Disease Control, Center for Disease Prevention, Korea Centers for Disease Control and Prevention, Osong, Korea Division of Chronic Disease Control, Center for Disease Prevention, Korea Centers for Disease Control and Prevention, Osong, Korea Division of Chronic Disease Control, Center for Disease Prevention, Korea Centers for Disease Control and Prevention, Osong, Korea Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaObjective To investigate longitudinal changes in language function in left-hemispheric ischemic stroke patients as well as factors that influence language recovery until 1 year after stroke onset. Methods We analyzed data from 235 patients with first-ever left-hemispheric ischemic stroke. All patients completed the Korean version of the Frenchay Aphasia Screening Test (K-FAST) at 7 days (T1), 3 months (T2), 6 months (T3), and 1 year (T4) after stroke onset. Repeated measures analysis of variance (ANOVA) was used to investigate changes in language function between time points. Subgroup analysis was performed according to the K-FAST scores at T1. Stroke lesion volume was assessed using diffusion tensor images, and involvement of language-related brain regions was examined. Multiple regression analysis was used to analyze factors influencing improvement of K-FAST score. Results The K-FAST scores at T1, T2, T3, and T4 differed significantly (p<0.05). In the subgroup analysis, only the severe group showed continuous significant improvement by 1 year. Factors that negatively influenced improvement of language function were the age at onset, initial National Institutes of Health Stroke Scale (NIHSS) score, and initial K-FAST score, whereas education level and stroke lesion volume positively affected recovery. Involvement of language-related brain regions did not significantly influence long-term language recovery after ischemic stroke. Conclusion Recovery of language function varied according to the severity of the initial language deficit. The age at stroke onset, education level, initial severity of aphasia, initial NIHSS score, and total stroke lesion volume were found to be important factors for recovery of language function.http://www.e-arm.org/upload/pdf/arm-2019-43-6-625.pdfstrokeaphasiaprognosisstroke volumerehabilitation |
| spellingShingle | Kyung Ah Kim Jung Soo Lee Won Hyuk Chang Deog Young Kim Yong-Il Shin Soo-Yeon Kim Young Taek Kim Sung Hyun Kang Ji Yoo Choi Yun-Hee Kim Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke Annals of Rehabilitation Medicine stroke aphasia prognosis stroke volume rehabilitation |
| title | Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke |
| title_full | Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke |
| title_fullStr | Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke |
| title_full_unstemmed | Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke |
| title_short | Changes in Language Function and Recovery-Related Prognostic Factors in First-Ever Left Hemispheric Ischemic Stroke |
| title_sort | changes in language function and recovery related prognostic factors in first ever left hemispheric ischemic stroke |
| topic | stroke aphasia prognosis stroke volume rehabilitation |
| url | http://www.e-arm.org/upload/pdf/arm-2019-43-6-625.pdf |
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