Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB
Sarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran,...
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| Format: | Article |
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Dove Medical Press
2019-09-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/benefit-effect-of-rem-sleep-deprivation-on-memory-impairment-induced-b-peer-reviewed-article-NSS |
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| author | Mahboubi S Nasehi M Imani A Sadat-Shirazi MS Zarrindast MR Vousooghi N Noroozian M |
| author_facet | Mahboubi S Nasehi M Imani A Sadat-Shirazi MS Zarrindast MR Vousooghi N Noroozian M |
| author_sort | Mahboubi S |
| collection | DOAJ |
| description | Sarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 4Department of Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 7Department of Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran; 8Memory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Maryam NoroozianMemory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Avenue, P.O. Box 1333795914, Tehran, IranTel +98 21 55 419 1515Fax +98 21 5 541 9113Email mnoroozi@tums.ac.irBackground: Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount.Purpose: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC).Material and methods: Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.Results: After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.Conclusion: The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.Keywords: intensive exercise, sleep deprivation, spatial memory, hippocampus, prefrontal cortex, BDNF, TrkB |
| first_indexed | 2024-12-14T14:20:55Z |
| format | Article |
| id | doaj.art-8320ccac541d410ea5c2c7bd2f74f605 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-12-14T14:20:55Z |
| publishDate | 2019-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-8320ccac541d410ea5c2c7bd2f74f6052022-12-21T22:58:05ZengDove Medical PressNature and Science of Sleep1179-16082019-09-01Volume 1117918848792Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkBMahboubi SNasehi MImani ASadat-Shirazi MSZarrindast MRVousooghi NNoroozian MSarah Mahboubi,1 Mohammad Nasehi,2 Alireza Imani,3,4 Mitra-Sadat Sadat-Shirazi,1–5 Mohammad-Reza Zarrindast,5–7 Nasim Vousooghi,1 Maryam Noroozian1–8 1Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; 4Department of Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran; 5Department of Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 7Department of Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran; 8Memory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, IranCorrespondence: Maryam NoroozianMemory and Behavioral Neurology Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Avenue, P.O. Box 1333795914, Tehran, IranTel +98 21 55 419 1515Fax +98 21 5 541 9113Email mnoroozi@tums.ac.irBackground: Many factors affect our learning and memory quality, but according to different studies, having a positive or negative impact pertains to their characteristics like intensity or the amount.Purpose: The present study was conducted to investigate the effect of 24-hour REM-sleep deprivation on continuous-high intensity forced exercise-induced memory impairment and its effect on Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine kinase B (TrkB) levels in the hippocampus and Prefrontal Cortex area (PFC).Material and methods: Animals were conditioned to run on treadmills for 5 weeks then, were deprived of sleep for 24 h using the modified multiple platforms. The effect of intensive exercise and/or 24-h REM-SD was studied on behavioral performance using Morris Water Maze protocol for 2 days, and BDNF/TrkB levels were assessed in hippocampus and PFC after behavioral probe test using western blotting.Results: After 5 weeks of intensive exercise and 24-h REM-SD, spatial memory impairment and reduction of BDNF and TrkB levels were found in hippocampus and PFC. 24-h REM-SD improved memory impairment and intensive exercise-induced downregulation of BDNF and TrkB protein levels.Conclusion: The results of the study suggested that sleep deprivation might act as a compensatory factor to reduce memory impairment when the animal is under severe stressful condition.Keywords: intensive exercise, sleep deprivation, spatial memory, hippocampus, prefrontal cortex, BDNF, TrkBhttps://www.dovepress.com/benefit-effect-of-rem-sleep-deprivation-on-memory-impairment-induced-b-peer-reviewed-article-NSSIntensive exerciseSleep DeprivationSpatial MemoryHippocampusPrefrontal CortexBDNFTrkB |
| spellingShingle | Mahboubi S Nasehi M Imani A Sadat-Shirazi MS Zarrindast MR Vousooghi N Noroozian M Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB Nature and Science of Sleep Intensive exercise Sleep Deprivation Spatial Memory Hippocampus Prefrontal Cortex BDNF TrkB |
| title | Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB |
| title_full | Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB |
| title_fullStr | Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB |
| title_full_unstemmed | Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB |
| title_short | Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB |
| title_sort | benefit effect of rem sleep deprivation on memory impairment induced by intensive exercise in male wistar rats with respect to hippocampal bdnf and trkb |
| topic | Intensive exercise Sleep Deprivation Spatial Memory Hippocampus Prefrontal Cortex BDNF TrkB |
| url | https://www.dovepress.com/benefit-effect-of-rem-sleep-deprivation-on-memory-impairment-induced-b-peer-reviewed-article-NSS |
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