Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer

Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer

Celastrol is a promising antitumor drug candidate, but the poor water solubility and cytotoxicity limit its clinical application. Herein, we synthesized a Celastrol (Cel)-chitosan oligosaccharide (CSO) conjugate (Cel-CSO) for drug delivery. Celastrol was conjugated to a CSO backbone via amide bond f...

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Bibliographic Details
Main Authors: Xiaohu Zeng, Xin Zhu, Qikang Tian, Xiaoke Tan, Ning Sun, Min Yan, Junwei Zhao, Xiangxiang Wu, Ruiqin Li, Zhenqiang Zhang, Huahui Zeng
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Drug Delivery
Subjects:
celastrol
chitosan oligosaccharide
pancreatic cancer
toxicity
drug delivery system
Online Access:http://dx.doi.org/10.1080/10717544.2021.2018521

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