Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study
BackgroundAutonomous motivation to exercise occurs when the activity is voluntary and with a perceived inherent satisfaction from the activity itself. It has been suggested that autonomous motivation is related to striatal dopamine D2/3-receptor (D2/3R) availability within the brain. In this study,...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.997131/full |
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| author | Emma Simonsson Emma Simonsson Lars Jonasson Stiernman Lars Jonasson Stiernman Anders Lundquist Anders Lundquist Erik Rosendahl Mattias Hedlund Nina Lindelöf Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk |
| author_facet | Emma Simonsson Emma Simonsson Lars Jonasson Stiernman Lars Jonasson Stiernman Anders Lundquist Anders Lundquist Erik Rosendahl Mattias Hedlund Nina Lindelöf Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk |
| author_sort | Emma Simonsson |
| collection | DOAJ |
| description | BackgroundAutonomous motivation to exercise occurs when the activity is voluntary and with a perceived inherent satisfaction from the activity itself. It has been suggested that autonomous motivation is related to striatal dopamine D2/3-receptor (D2/3R) availability within the brain. In this study, we hypothesized that D2/3R availability in three striatal regions (nucleus accumbens, caudate nucleus, and putamen) would be positively associated with self-reported autonomous motivation to exercise. We also examined this relationship with additional exploratory analyses across a set of a priori extrastriatal regions of interest (ROI).MethodsOur sample comprised 49 older adults (28 females) between 64 and 78 years of age. The D2/3R availability was quantified from positron emission tomography using the non-displaceable binding potential of [11C]-raclopride ligand. The exercise-related autonomous motivation was assessed with the Swedish version of the Behavioral Regulations in Exercise Questionnaire-2.ResultsNo significant associations were observed between self-reported autonomous motivation to exercise and D2/3R availability within the striatum (nucleus accumbens, caudate nucleus, and putamen) using semi-partial correlations controlling for ROI volume on D2/3R availability. For exploratory analyses, positive associations were observed for the superior (r = 0.289, p = 0.023) and middle frontal gyrus (r = 0.330, p = 0.011), but not for the inferior frontal gyrus, orbitofrontal cortex, anterior cingulate cortex, or anterior insular cortex.ConclusionThis study could not confirm the suggested link between striatal D2/3R availability and subjective autonomous motivation to exercise among older adults. The exploratory findings, however, propose that frontal brain regions may be involved in the intrinsic regulation of exercise-related behaviors, though this has to be confirmed by future studies using a more suitable ligand and objective measures of physical activity levels. |
| first_indexed | 2024-04-11T16:37:01Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-11T16:37:01Z |
| publishDate | 2022-11-01 |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-832297ff5e514651b2728f83e57ebdbb2022-12-22T04:13:47ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-11-011610.3389/fnhum.2022.997131997131Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride studyEmma Simonsson0Emma Simonsson1Lars Jonasson Stiernman2Lars Jonasson Stiernman3Anders Lundquist4Anders Lundquist5Erik Rosendahl6Mattias Hedlund7Nina Lindelöf8Carl-Johan Boraxbekk9Carl-Johan Boraxbekk10Carl-Johan Boraxbekk11Carl-Johan Boraxbekk12Carl-Johan Boraxbekk13Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, SwedenUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, SwedenUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, SwedenDepartment of Integrative Medical Biology, Umeå University, Umeå, SwedenUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, SwedenDepartment of Statistics, Umeå School of Business, Economics and Statistics, Umeå University, Umeå, SwedenDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, SwedenDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, SwedenDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, SwedenUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, SwedenDepartment of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, SwedenDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, DenmarkDepartment of Neurology, Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital Bispebjerg, Copenhagen, DenmarkFaculty of Medical and Health Sciences, Institute for Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkBackgroundAutonomous motivation to exercise occurs when the activity is voluntary and with a perceived inherent satisfaction from the activity itself. It has been suggested that autonomous motivation is related to striatal dopamine D2/3-receptor (D2/3R) availability within the brain. In this study, we hypothesized that D2/3R availability in three striatal regions (nucleus accumbens, caudate nucleus, and putamen) would be positively associated with self-reported autonomous motivation to exercise. We also examined this relationship with additional exploratory analyses across a set of a priori extrastriatal regions of interest (ROI).MethodsOur sample comprised 49 older adults (28 females) between 64 and 78 years of age. The D2/3R availability was quantified from positron emission tomography using the non-displaceable binding potential of [11C]-raclopride ligand. The exercise-related autonomous motivation was assessed with the Swedish version of the Behavioral Regulations in Exercise Questionnaire-2.ResultsNo significant associations were observed between self-reported autonomous motivation to exercise and D2/3R availability within the striatum (nucleus accumbens, caudate nucleus, and putamen) using semi-partial correlations controlling for ROI volume on D2/3R availability. For exploratory analyses, positive associations were observed for the superior (r = 0.289, p = 0.023) and middle frontal gyrus (r = 0.330, p = 0.011), but not for the inferior frontal gyrus, orbitofrontal cortex, anterior cingulate cortex, or anterior insular cortex.ConclusionThis study could not confirm the suggested link between striatal D2/3R availability and subjective autonomous motivation to exercise among older adults. The exploratory findings, however, propose that frontal brain regions may be involved in the intrinsic regulation of exercise-related behaviors, though this has to be confirmed by future studies using a more suitable ligand and objective measures of physical activity levels.https://www.frontiersin.org/articles/10.3389/fnhum.2022.997131/fullautonomous motivationexercise motivationself-determination theory (SDT)dopaminePETaging |
| spellingShingle | Emma Simonsson Emma Simonsson Lars Jonasson Stiernman Lars Jonasson Stiernman Anders Lundquist Anders Lundquist Erik Rosendahl Mattias Hedlund Nina Lindelöf Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Carl-Johan Boraxbekk Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study Frontiers in Human Neuroscience autonomous motivation exercise motivation self-determination theory (SDT) dopamine PET aging |
| title | Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study |
| title_full | Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study |
| title_fullStr | Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study |
| title_full_unstemmed | Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study |
| title_short | Dopamine D2/3-receptor availability and its association with autonomous motivation to exercise in older adults: An exploratory [11C]-raclopride study |
| title_sort | dopamine d2 3 receptor availability and its association with autonomous motivation to exercise in older adults an exploratory 11c raclopride study |
| topic | autonomous motivation exercise motivation self-determination theory (SDT) dopamine PET aging |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.997131/full |
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