Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity
ABSTRACTTick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortly after infection, with clinical manifestations, seve...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2317909 |
| _version_ | 1797300509968695296 |
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| author | Amare Aregay Jan Slunečko Petra Bogovic Miša Korva Katarina Resman Rus Nataša Knap Jana Beicht Mareike Kubinski Giulietta Saletti Imke Steffen Franc Strle Tatjana Avšič-Županc Albert D.M.E. Osterhaus Guus F. Rimmelzwaan |
| author_facet | Amare Aregay Jan Slunečko Petra Bogovic Miša Korva Katarina Resman Rus Nataša Knap Jana Beicht Mareike Kubinski Giulietta Saletti Imke Steffen Franc Strle Tatjana Avšič-Županc Albert D.M.E. Osterhaus Guus F. Rimmelzwaan |
| author_sort | Amare Aregay |
| collection | DOAJ |
| description | ABSTRACTTick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and long-term outcome has been poorly investigated. In a cohort of thirty early tick-borne encephalitis (TBE) patients, we assessed the magnitude, specificity and functional properties of TBEV-specific T-cell and antibody responses. These responses early during disease were assessed in view of clinical manifestations, severity and long-term outcome. TBEV-specific T-cell responses to C, E, NS1, and NS5 proteins were significantly lower in patients with severe acute illness than in patients with mild TBE. Lower T-cell responses to E, NS1, and NS5 proteins also correlated with the development of meningoencephalomyelitis. Virus-specific antibody titres early after infection did not correlate with disease severity, clinical manifestations, or long-term outcome in this study, possibly due to the small number of patients of which matching serum and peripheral blood mononuclear cells were available. The findings suggest that virus-specific T cells afford a certain degree of protection against the development of severe TBEV-induced disease. |
| first_indexed | 2024-03-07T23:08:11Z |
| format | Article |
| id | doaj.art-8322d2c58d7a4e8190e93eb9a95a774a |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-07T23:08:11Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-8322d2c58d7a4e8190e93eb9a95a774a2024-02-21T20:49:12ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2317909Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severityAmare Aregay0Jan Slunečko1Petra Bogovic2Miša Korva3Katarina Resman Rus4Nataša Knap5Jana Beicht6Mareike Kubinski7Giulietta Saletti8Imke Steffen9Franc Strle10Tatjana Avšič-Županc11Albert D.M.E. Osterhaus12Guus F. Rimmelzwaan13Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyFaculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Ljubljana, SloveniaDepartment of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Ljubljana, SloveniaResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyDepartment of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Institute for Microbiology and Immunology, University of Ljubljana, Ljubljana, SloveniaResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyResearch Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Foundation, Hannover, GermanyABSTRACTTick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and long-term outcome has been poorly investigated. In a cohort of thirty early tick-borne encephalitis (TBE) patients, we assessed the magnitude, specificity and functional properties of TBEV-specific T-cell and antibody responses. These responses early during disease were assessed in view of clinical manifestations, severity and long-term outcome. TBEV-specific T-cell responses to C, E, NS1, and NS5 proteins were significantly lower in patients with severe acute illness than in patients with mild TBE. Lower T-cell responses to E, NS1, and NS5 proteins also correlated with the development of meningoencephalomyelitis. Virus-specific antibody titres early after infection did not correlate with disease severity, clinical manifestations, or long-term outcome in this study, possibly due to the small number of patients of which matching serum and peripheral blood mononuclear cells were available. The findings suggest that virus-specific T cells afford a certain degree of protection against the development of severe TBEV-induced disease.https://www.tandfonline.com/doi/10.1080/22221751.2024.2317909TBEV; Tick-Borne Encephalitis (TBE); TBEV-specific T-cells; disease severity; outcome |
| spellingShingle | Amare Aregay Jan Slunečko Petra Bogovic Miša Korva Katarina Resman Rus Nataša Knap Jana Beicht Mareike Kubinski Giulietta Saletti Imke Steffen Franc Strle Tatjana Avšič-Županc Albert D.M.E. Osterhaus Guus F. Rimmelzwaan Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity Emerging Microbes and Infections TBEV; Tick-Borne Encephalitis (TBE); TBEV-specific T-cells; disease severity; outcome |
| title | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity |
| title_full | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity |
| title_fullStr | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity |
| title_full_unstemmed | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity |
| title_short | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity |
| title_sort | poor virus specific t cell responses early after tick borne encephalitis virus infection correlate with disease severity |
| topic | TBEV; Tick-Borne Encephalitis (TBE); TBEV-specific T-cells; disease severity; outcome |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2317909 |
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