Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province
Background & Aims: Aflatoxin M1 (AFM1) is a major metabolite of aflatoxin B1 detected in the milk of mammals that their foods have been contaminated with aflatoxins. Aflatoxins are a group of highly toxic metabolites produced by the common fungi Aspergillus flavus, A. parasiticus. They are among...
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| Format: | Article |
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Kerman University of Medical Sciences
2009-07-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_17274_f88c9968796e92314184427a7e872ba5.pdf |
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| author | SH Pournormohammadi M Ansari L Nezafati olfati M Kazemipour M Hasibi |
| author_facet | SH Pournormohammadi M Ansari L Nezafati olfati M Kazemipour M Hasibi |
| author_sort | SH Pournormohammadi |
| collection | DOAJ |
| description | Background & Aims: Aflatoxin M1 (AFM1) is a major metabolite of aflatoxin B1 detected in the milk of mammals that their foods have been contaminated with aflatoxins. Aflatoxins are a group of highly toxic metabolites produced by the common fungi Aspergillus flavus, A. parasiticus. They are among the most potent carcinogens found in foods. Considering its risk to the human health and high consumption of milk and diary products, this study was undertaken to determine the level of AFM1in pasteurized milk in Kerman province for the first time. Method: From 19 Dec. 2007 to 19 March 2008, a total of 76 pasteurized milk samples produced by eight factories were collected and checked for the level of AFM1 using immunoaffinity column and highperformance liquid chromatography coupled to fluorimetric detector. Results: The minimum detected level was 0.002 ppb and the amount of AFM1 in milk samples ranged from 0.002 to 0.14 ppb. No sample had greater AFM1 levels than the maximum allowed levels in milk accepted by FDA (o.5ppb), however, in 34 (44.7%) samples AFM1 level was over the maximum allowed limit in milk accepted by the European Union (0.05ppb). Mean AFM1 level in milk samples obtained from Jiroft factory was the least (0.019±0.01ppb) compared to that for other factories. Conclusion: Although the amount of AFM1 in samples selected from commonly consumed milks in Kerman province, does not appear to create a serious public health problem at present, because of high consumption of milk and diary products especially in children it is necessary to consider it as a serious health problem. |
| first_indexed | 2024-03-13T02:07:12Z |
| format | Article |
| id | doaj.art-83254ecca7ff4d9dab9eca4e0dfbd697 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:07:12Z |
| publishDate | 2009-07-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-83254ecca7ff4d9dab9eca4e0dfbd6972023-07-01T05:33:45ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432009-07-0116327128017274Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman ProvinceSH Pournormohammadi0M Ansari1L Nezafati olfati2M Kazemipour3M Hasibi4Assistant Professor of Toxicology, School of Pharmacy, Pharmaceutics Research Center & Physiology Research Center, Kerman University of Medical Sciences, Kerman, IranAssociate professor of Pharmaceutics, School of pharmacy, Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, IranM.Sc. Student of Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, IranAssociate Professor of Analytical Chemistry, Islamic Azad University, Kerman Branch, Kerman, IranPharmacist, Food Control Office, Kerman University of Medical Sciences, Kerman, IranBackground & Aims: Aflatoxin M1 (AFM1) is a major metabolite of aflatoxin B1 detected in the milk of mammals that their foods have been contaminated with aflatoxins. Aflatoxins are a group of highly toxic metabolites produced by the common fungi Aspergillus flavus, A. parasiticus. They are among the most potent carcinogens found in foods. Considering its risk to the human health and high consumption of milk and diary products, this study was undertaken to determine the level of AFM1in pasteurized milk in Kerman province for the first time. Method: From 19 Dec. 2007 to 19 March 2008, a total of 76 pasteurized milk samples produced by eight factories were collected and checked for the level of AFM1 using immunoaffinity column and highperformance liquid chromatography coupled to fluorimetric detector. Results: The minimum detected level was 0.002 ppb and the amount of AFM1 in milk samples ranged from 0.002 to 0.14 ppb. No sample had greater AFM1 levels than the maximum allowed levels in milk accepted by FDA (o.5ppb), however, in 34 (44.7%) samples AFM1 level was over the maximum allowed limit in milk accepted by the European Union (0.05ppb). Mean AFM1 level in milk samples obtained from Jiroft factory was the least (0.019±0.01ppb) compared to that for other factories. Conclusion: Although the amount of AFM1 in samples selected from commonly consumed milks in Kerman province, does not appear to create a serious public health problem at present, because of high consumption of milk and diary products especially in children it is necessary to consider it as a serious health problem.https://jkmu.kmu.ac.ir/article_17274_f88c9968796e92314184427a7e872ba5.pdfmilkaflatoxin m1hplckerman |
| spellingShingle | SH Pournormohammadi M Ansari L Nezafati olfati M Kazemipour M Hasibi Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province Journal of Kerman University of Medical Sciences milk aflatoxin m1 hplc kerman |
| title | Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province |
| title_full | Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province |
| title_fullStr | Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province |
| title_full_unstemmed | Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province |
| title_short | Determination of Aflatoxin M1 in Pasteurized Milk Consumed in Kerman Province |
| title_sort | determination of aflatoxin m1 in pasteurized milk consumed in kerman province |
| topic | milk aflatoxin m1 hplc kerman |
| url | https://jkmu.kmu.ac.ir/article_17274_f88c9968796e92314184427a7e872ba5.pdf |
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