Time to achieve a patient acceptable symptom state in myasthenia gravis
IntroductionThe patient acceptable symptom state (PASS) is a reliable way to characterize a patient’s satisfaction with their disease state in a “Yes”/“No” dichotomous manner. There is limited data on the time required to reach an acceptable state in Myasthenia Gravis (MG). We aimed to determine the...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1187189/full |
| _version_ | 1797802595557834752 |
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| author | Rodrigo Martinez-Harms Rodrigo Martinez-Harms Carolina Barnett Carolina Barnett Vera Bril Vera Bril |
| author_facet | Rodrigo Martinez-Harms Rodrigo Martinez-Harms Carolina Barnett Carolina Barnett Vera Bril Vera Bril |
| author_sort | Rodrigo Martinez-Harms |
| collection | DOAJ |
| description | IntroductionThe patient acceptable symptom state (PASS) is a reliable way to characterize a patient’s satisfaction with their disease state in a “Yes”/“No” dichotomous manner. There is limited data on the time required to reach an acceptable state in Myasthenia Gravis (MG). We aimed to determine the time to reach a first PASS “Yes” response in patients at MG diagnosis and a PASS “No” status, and also to determine the influence of various factors on this time.MethodsWe performed a retrospective study of patients diagnosed with myasthenia gravis who had an initial PASS “No” response and defined the time to reach a first PASS “Yes” by Kaplan–Meier analysis. Correlations were made between demographics, clinical characteristics, treatment and disease severity, using the Myasthenia Gravis Impairment Index (MGII) and Simple Single Question (SSQ).ResultsIn 86 patients meeting inclusion criteria, the median time to PASS “Yes” was 15 months (95% CI 11–18). Of 67 MG patients who achieved PASS “Yes,” 61 (91%), achieved it by 25 months after diagnosis. Patients who required only prednisone therapy achieved PASS “Yes” in a shorter time with a median of 5.5 months (p = 0.01). Very-late-onset MG patients reached PASS “Yes” status in a shorter time (HR = 1.99, 95% CI 0.26–2.63; p = 0.001).DiscussionMost patients reached PASS “Yes” by 25 months after diagnosis. MG patients who only required prednisone and those with very-late-onset MG reach PASS “Yes” in shorter intervals. |
| first_indexed | 2024-03-13T05:09:01Z |
| format | Article |
| id | doaj.art-8326f7095f7f432cb093135a1978b4c8 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T05:09:01Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-8326f7095f7f432cb093135a1978b4c82023-06-16T06:12:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-06-011410.3389/fneur.2023.11871891187189Time to achieve a patient acceptable symptom state in myasthenia gravisRodrigo Martinez-Harms0Rodrigo Martinez-Harms1Carolina Barnett2Carolina Barnett3Vera Bril4Vera Bril5Ellen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, Toronto, ON, CanadaDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, CanadaEllen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, Toronto, ON, CanadaDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, CanadaEllen & Martin Prosserman Centre for Neuromuscular Diseases, Toronto General Hospital, Toronto, ON, CanadaDepartment of Medicine, University Health Network, University of Toronto, Toronto, ON, CanadaIntroductionThe patient acceptable symptom state (PASS) is a reliable way to characterize a patient’s satisfaction with their disease state in a “Yes”/“No” dichotomous manner. There is limited data on the time required to reach an acceptable state in Myasthenia Gravis (MG). We aimed to determine the time to reach a first PASS “Yes” response in patients at MG diagnosis and a PASS “No” status, and also to determine the influence of various factors on this time.MethodsWe performed a retrospective study of patients diagnosed with myasthenia gravis who had an initial PASS “No” response and defined the time to reach a first PASS “Yes” by Kaplan–Meier analysis. Correlations were made between demographics, clinical characteristics, treatment and disease severity, using the Myasthenia Gravis Impairment Index (MGII) and Simple Single Question (SSQ).ResultsIn 86 patients meeting inclusion criteria, the median time to PASS “Yes” was 15 months (95% CI 11–18). Of 67 MG patients who achieved PASS “Yes,” 61 (91%), achieved it by 25 months after diagnosis. Patients who required only prednisone therapy achieved PASS “Yes” in a shorter time with a median of 5.5 months (p = 0.01). Very-late-onset MG patients reached PASS “Yes” status in a shorter time (HR = 1.99, 95% CI 0.26–2.63; p = 0.001).DiscussionMost patients reached PASS “Yes” by 25 months after diagnosis. MG patients who only required prednisone and those with very-late-onset MG reach PASS “Yes” in shorter intervals.https://www.frontiersin.org/articles/10.3389/fneur.2023.1187189/fullmyasthenia gravispatient acceptable symptom statemyasthenia gravis impairment indexsingle simple questionsatisfactory disease status |
| spellingShingle | Rodrigo Martinez-Harms Rodrigo Martinez-Harms Carolina Barnett Carolina Barnett Vera Bril Vera Bril Time to achieve a patient acceptable symptom state in myasthenia gravis Frontiers in Neurology myasthenia gravis patient acceptable symptom state myasthenia gravis impairment index single simple question satisfactory disease status |
| title | Time to achieve a patient acceptable symptom state in myasthenia gravis |
| title_full | Time to achieve a patient acceptable symptom state in myasthenia gravis |
| title_fullStr | Time to achieve a patient acceptable symptom state in myasthenia gravis |
| title_full_unstemmed | Time to achieve a patient acceptable symptom state in myasthenia gravis |
| title_short | Time to achieve a patient acceptable symptom state in myasthenia gravis |
| title_sort | time to achieve a patient acceptable symptom state in myasthenia gravis |
| topic | myasthenia gravis patient acceptable symptom state myasthenia gravis impairment index single simple question satisfactory disease status |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1187189/full |
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