Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer
Aim: Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. Materials & methods: We retrospectively enrolled 1146 patients diagnosed with stage I–II triple-negative breast cancer. Disease-free and overall survival were analyzed using...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Future Science Ltd
2023-11-01
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| Series: | Future Science OA |
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| Online Access: | https://www.future-science.com/doi/10.2144/fsoa-2023-0129 |
| _version_ | 1797500515704111104 |
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| author | Fengyan Li Xinhui Zhou Wendie Hu Yujie Du Jiayuan Sun Yaxue Wang |
| author_facet | Fengyan Li Xinhui Zhou Wendie Hu Yujie Du Jiayuan Sun Yaxue Wang |
| author_sort | Fengyan Li |
| collection | DOAJ |
| description | Aim: Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. Materials & methods: We retrospectively enrolled 1146 patients diagnosed with stage I–II triple-negative breast cancer. Disease-free and overall survival were analyzed using the Kaplan–Meier method and the Cox regression model. Results: We classified Ki-67 >45% as the high group (n = 716). A Ki-67 level of >45% was associated with poorer disease-free survival (p = 0.039) and overall survival (p = 0.029). Lymph node stage, neoadjuvant chemotherapy, and radiotherapy were independent predictive variables of prognosis. Conclusion: Triple-negative breast cancer may be further subcategorized according to the Ki-67 level. Neoadjuvant chemotherapy and postoperative radiotherapy can improve the prognosis of early triple-negative breast cancer. |
| first_indexed | 2024-03-10T03:03:57Z |
| format | Article |
| id | doaj.art-8328100232cc4c7e92efaa3133f60f18 |
| institution | Directory Open Access Journal |
| issn | 2056-5623 |
| language | English |
| last_indexed | 2024-03-10T03:03:57Z |
| publishDate | 2023-11-01 |
| publisher | Future Science Ltd |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj.art-8328100232cc4c7e92efaa3133f60f182023-11-23T10:36:58ZengFuture Science LtdFuture Science OA2056-56232023-11-0110.2144/fsoa-2023-0129Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancerFengyan Li0Xinhui Zhou1Wendie Hu2Yujie Du3Jiayuan Sun4Yaxue Wang51State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR ChinaAim: Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. Materials & methods: We retrospectively enrolled 1146 patients diagnosed with stage I–II triple-negative breast cancer. Disease-free and overall survival were analyzed using the Kaplan–Meier method and the Cox regression model. Results: We classified Ki-67 >45% as the high group (n = 716). A Ki-67 level of >45% was associated with poorer disease-free survival (p = 0.039) and overall survival (p = 0.029). Lymph node stage, neoadjuvant chemotherapy, and radiotherapy were independent predictive variables of prognosis. Conclusion: Triple-negative breast cancer may be further subcategorized according to the Ki-67 level. Neoadjuvant chemotherapy and postoperative radiotherapy can improve the prognosis of early triple-negative breast cancer.https://www.future-science.com/doi/10.2144/fsoa-2023-0129Ki-67neoadjuvant chemotherapypostoperative radiotherapyprognosistriple-negative breast cancer |
| spellingShingle | Fengyan Li Xinhui Zhou Wendie Hu Yujie Du Jiayuan Sun Yaxue Wang Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer Future Science OA Ki-67 neoadjuvant chemotherapy postoperative radiotherapy prognosis triple-negative breast cancer |
| title | Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer |
| title_full | Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer |
| title_fullStr | Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer |
| title_full_unstemmed | Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer |
| title_short | Prognostic predictive value of Ki-67 in stage I–II triple-negative breast cancer |
| title_sort | prognostic predictive value of ki 67 in stage i ii triple negative breast cancer |
| topic | Ki-67 neoadjuvant chemotherapy postoperative radiotherapy prognosis triple-negative breast cancer |
| url | https://www.future-science.com/doi/10.2144/fsoa-2023-0129 |
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