In Vitro Persistence Level Reflects In Vivo Antibiotic Survival of Natural Pseudomonas aeruginosa Isolates in a Murine Lung Infection Model

In Vitro Persistence Level Reflects In Vivo Antibiotic Survival of Natural Pseudomonas aeruginosa Isolates in a Murine Lung Infection Model

ABSTRACT Clinicians are increasingly confronted with the limitations of antibiotics to clear bacterial infections in patients. It has long been assumed that only antibiotic resistance plays a pivotal role in this phenomenon. Indeed, the worldwide emergence of antibiotic resistance is considered one...

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Bibliographic Details
Main Authors: Laure Verstraete, Juliana Aizawa, Matthias Govaerts, Linda De Vooght, Rob Lavigne, Jan Michiels, Bram Van den Bergh, Paul Cos
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
persistence
antibiotics
tolerance
Pseudomonas aeruginosa
in vivo model
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04970-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04970-22

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