Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases
Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct respiratory diseases that share features such as the obstruction of small airways and disease flare-ups that are called exacerbations and are often caused by infections. Along the airway epithelium, immunoglob...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/8/1324 |
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| author | Charlotte de Fays François M. Carlier Sophie Gohy Charles Pilette |
| author_facet | Charlotte de Fays François M. Carlier Sophie Gohy Charles Pilette |
| author_sort | Charlotte de Fays |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct respiratory diseases that share features such as the obstruction of small airways and disease flare-ups that are called exacerbations and are often caused by infections. Along the airway epithelium, immunoglobulin (Ig) A contributes to first line mucosal protection against inhaled particles and pathogens. Dimeric IgA produced by mucosal plasma cells is transported towards the apical pole of airway epithelial cells by the polymeric Ig receptor (pIgR), where it is released as secretory IgA. Secretory IgA mediates immune exclusion and promotes the clearance of pathogens from the airway surface by inhibiting their adherence to the epithelium. In this review, we summarize the current knowledge regarding alterations of the IgA/pIgR system observed in those major obstructive airway diseases and discuss their implication for disease pathogenesis. |
| first_indexed | 2024-03-09T11:01:17Z |
| format | Article |
| id | doaj.art-832c200f26464f0b9f32ffc3ba40f416 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T11:01:17Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-832c200f26464f0b9f32ffc3ba40f4162023-12-01T01:14:26ZengMDPI AGCells2073-44092022-04-01118132410.3390/cells11081324Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory DiseasesCharlotte de Fays0François M. Carlier1Sophie Gohy2Charles Pilette3Pole of Pneumology, ENT, and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200 Brussels, BelgiumPole of Pneumology, ENT, and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200 Brussels, BelgiumPole of Pneumology, ENT, and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200 Brussels, BelgiumPole of Pneumology, ENT, and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain, 1200 Brussels, BelgiumChronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct respiratory diseases that share features such as the obstruction of small airways and disease flare-ups that are called exacerbations and are often caused by infections. Along the airway epithelium, immunoglobulin (Ig) A contributes to first line mucosal protection against inhaled particles and pathogens. Dimeric IgA produced by mucosal plasma cells is transported towards the apical pole of airway epithelial cells by the polymeric Ig receptor (pIgR), where it is released as secretory IgA. Secretory IgA mediates immune exclusion and promotes the clearance of pathogens from the airway surface by inhibiting their adherence to the epithelium. In this review, we summarize the current knowledge regarding alterations of the IgA/pIgR system observed in those major obstructive airway diseases and discuss their implication for disease pathogenesis.https://www.mdpi.com/2073-4409/11/8/1324immunoglobulin Amucosal immunitypIgRCOPDasthmacystic fibrosis |
| spellingShingle | Charlotte de Fays François M. Carlier Sophie Gohy Charles Pilette Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases Cells immunoglobulin A mucosal immunity pIgR COPD asthma cystic fibrosis |
| title | Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases |
| title_full | Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases |
| title_fullStr | Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases |
| title_full_unstemmed | Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases |
| title_short | Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases |
| title_sort | secretory immunoglobulin a immunity in chronic obstructive respiratory diseases |
| topic | immunoglobulin A mucosal immunity pIgR COPD asthma cystic fibrosis |
| url | https://www.mdpi.com/2073-4409/11/8/1324 |
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