The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states
Spatially and temporally resolved data can improve our understanding of evolution and treatment resistance in multiple myeloma (MM). Here, the authors analyse spatial and longitudinal heterogeneity in MM patients using multi-region sequencing, and identify subclones associated with relapse and thera...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32145-y |
| _version_ | 1818505131373625344 |
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| author | Leo Rasche Carolina Schinke Francesco Maura Michael A. Bauer Cody Ashby Shayu Deshpande Alexandra M. Poos Maurizio Zangari Sharmilan Thanendrarajan Faith E. Davies Brian A. Walker Bart Barlogie Ola Landgren Gareth J. Morgan Frits van Rhee Niels Weinhold |
| author_facet | Leo Rasche Carolina Schinke Francesco Maura Michael A. Bauer Cody Ashby Shayu Deshpande Alexandra M. Poos Maurizio Zangari Sharmilan Thanendrarajan Faith E. Davies Brian A. Walker Bart Barlogie Ola Landgren Gareth J. Morgan Frits van Rhee Niels Weinhold |
| author_sort | Leo Rasche |
| collection | DOAJ |
| description | Spatially and temporally resolved data can improve our understanding of evolution and treatment resistance in multiple myeloma (MM). Here, the authors analyse spatial and longitudinal heterogeneity in MM patients using multi-region sequencing, and identify subclones associated with relapse and therapy resistance. |
| first_indexed | 2024-12-10T21:46:37Z |
| format | Article |
| id | doaj.art-832c8c194632414993cfa4d014438ce1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T21:46:37Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-832c8c194632414993cfa4d014438ce12022-12-22T01:32:21ZengNature PortfolioNature Communications2041-17232022-08-0113111310.1038/s41467-022-32145-yThe spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory statesLeo Rasche0Carolina Schinke1Francesco Maura2Michael A. Bauer3Cody Ashby4Shayu Deshpande5Alexandra M. Poos6Maurizio Zangari7Sharmilan Thanendrarajan8Faith E. Davies9Brian A. Walker10Bart Barlogie11Ola Landgren12Gareth J. Morgan13Frits van Rhee14Niels Weinhold15Myeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Program, Sylvester Comprehensive Cancer Center, University of MiamiMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesDepartment of Internal Medicine V, University Hospital of HeidelbergMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesPerlmutter Cancer Center, New York University Langone HealthDivision of Hematology Oncology, Indiana UniversityMyeloma Center, University of Arkansas for Medical SciencesMyeloma Program, Sylvester Comprehensive Cancer Center, University of MiamiPerlmutter Cancer Center, New York University Langone HealthMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesSpatially and temporally resolved data can improve our understanding of evolution and treatment resistance in multiple myeloma (MM). Here, the authors analyse spatial and longitudinal heterogeneity in MM patients using multi-region sequencing, and identify subclones associated with relapse and therapy resistance.https://doi.org/10.1038/s41467-022-32145-y |
| spellingShingle | Leo Rasche Carolina Schinke Francesco Maura Michael A. Bauer Cody Ashby Shayu Deshpande Alexandra M. Poos Maurizio Zangari Sharmilan Thanendrarajan Faith E. Davies Brian A. Walker Bart Barlogie Ola Landgren Gareth J. Morgan Frits van Rhee Niels Weinhold The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states Nature Communications |
| title | The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states |
| title_full | The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states |
| title_fullStr | The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states |
| title_full_unstemmed | The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states |
| title_short | The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states |
| title_sort | spatio temporal evolution of multiple myeloma from baseline to relapse refractory states |
| url | https://doi.org/10.1038/s41467-022-32145-y |
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