SYNTHESIS AND STRUCTURE OF SOME N-ARYLBENZAMIDINES
The reaction of benzonitrile with some arylamines was studied. It was found that the structure of arylamines affects the yield of N-arylbenzamidines and the possibility of their obtainment, which was confirmed by quantum-chemical calculations. The reaction of benzonitrile with arylamines is thermody...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/508 |
| Summary: | The reaction of benzonitrile with some arylamines was studied. It was found that the structure of arylamines affects the yield of N-arylbenzamidines and the possibility of their obtainment, which was confirmed by quantum-chemical calculations. The reaction of benzonitrile with arylamines is thermodynamically controlled. Maximal yield of product was obtained at t=180°C. The structure of synthesized compounds was proved by means of modern physicochemical methods of analysis: NMR 1Н-, 13С-, 15N-spectroscopy, X-ray diffraction analysis (RSА). |
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| ISSN: | 2305-2066 2658-5049 |