SUITO Index for Evaluation of Clinical Islet Transplantation
The major endpoints for clinical islet transplantation for type 1 diabetes are insulin independence and reduction of hypoglycemic episodes. Both endpoints are influenced by patients' and physicians' preferences regarding the use of exogenous insulin. Therefore, development of an objective...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-07-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368912X636885 |
| _version_ | 1830452731152695296 |
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| author | Morihito Takita M.D., Ph.D. Shinichi Matusmoto |
| author_facet | Morihito Takita M.D., Ph.D. Shinichi Matusmoto |
| author_sort | Morihito Takita M.D., Ph.D. |
| collection | DOAJ |
| description | The major endpoints for clinical islet transplantation for type 1 diabetes are insulin independence and reduction of hypoglycemic episodes. Both endpoints are influenced by patients' and physicians' preferences regarding the use of exogenous insulin. Therefore, development of an objective endpoint for assessing clinical islet transplantation is desirable. HOMA-beta score is useful in assessing functional β-cell mass. However, this score uses blood insulin levels that are influenced by exogenous insulin injection and therefore is not suitable for patients who receive exogenous insulin. For assessing functional β-cell mass for type 1 diabetic patients after islet transplantation, we created the Secretory Unit of Islet Transplant Objects (SUITO) index using fasting C-peptide and fasting glucose. The formula of the SUITO index is fasting C-peptide (ng/ml)/[fasting blood glucose – 63 (mg/dl)] x 1500. We demonstrated that, within 1 month of islet transplantation, an average SUITO index of >26 was an excellent predictor of achieving insulin independence. In addition, daily SUITO index scores correlated with a reduction of insulin dose and adversely correlated with blood glucose levels during an intravenous glucose tolerance test. Other important endpoints, reduction of hypoglycemic episodes and quality of life, also correlated with the SUITO index. Thus, the SUITO index is excellent for assessing important endpoints (insulin independence, reduction of hypoglycemia, improved quality of life) after allogeneic islet transplantation. |
| first_indexed | 2024-12-21T08:54:34Z |
| format | Article |
| id | doaj.art-832e2989f64c4ad385759e0373bb7951 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-21T08:54:34Z |
| publishDate | 2012-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-832e2989f64c4ad385759e0373bb79512022-12-21T19:09:36ZengSAGE PublishingCell Transplantation0963-68971555-38922012-07-012110.3727/096368912X636885SUITO Index for Evaluation of Clinical Islet TransplantationMorihito Takita M.D., Ph.D.0Shinichi Matusmoto1 The Institute of Medical Science, University of Tokyo, Tokyo, Japan The Institute of Medical Science, University of Tokyo, Tokyo, JapanThe major endpoints for clinical islet transplantation for type 1 diabetes are insulin independence and reduction of hypoglycemic episodes. Both endpoints are influenced by patients' and physicians' preferences regarding the use of exogenous insulin. Therefore, development of an objective endpoint for assessing clinical islet transplantation is desirable. HOMA-beta score is useful in assessing functional β-cell mass. However, this score uses blood insulin levels that are influenced by exogenous insulin injection and therefore is not suitable for patients who receive exogenous insulin. For assessing functional β-cell mass for type 1 diabetic patients after islet transplantation, we created the Secretory Unit of Islet Transplant Objects (SUITO) index using fasting C-peptide and fasting glucose. The formula of the SUITO index is fasting C-peptide (ng/ml)/[fasting blood glucose – 63 (mg/dl)] x 1500. We demonstrated that, within 1 month of islet transplantation, an average SUITO index of >26 was an excellent predictor of achieving insulin independence. In addition, daily SUITO index scores correlated with a reduction of insulin dose and adversely correlated with blood glucose levels during an intravenous glucose tolerance test. Other important endpoints, reduction of hypoglycemic episodes and quality of life, also correlated with the SUITO index. Thus, the SUITO index is excellent for assessing important endpoints (insulin independence, reduction of hypoglycemia, improved quality of life) after allogeneic islet transplantation.https://doi.org/10.3727/096368912X636885 |
| spellingShingle | Morihito Takita M.D., Ph.D. Shinichi Matusmoto SUITO Index for Evaluation of Clinical Islet Transplantation Cell Transplantation |
| title | SUITO Index for Evaluation of Clinical Islet Transplantation |
| title_full | SUITO Index for Evaluation of Clinical Islet Transplantation |
| title_fullStr | SUITO Index for Evaluation of Clinical Islet Transplantation |
| title_full_unstemmed | SUITO Index for Evaluation of Clinical Islet Transplantation |
| title_short | SUITO Index for Evaluation of Clinical Islet Transplantation |
| title_sort | suito index for evaluation of clinical islet transplantation |
| url | https://doi.org/10.3727/096368912X636885 |
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