Role of Hydrogen Sulfide in Inflammatory Bowel Disease
Hydrogen sulfide (H<sub>2</sub>S), originally known as toxic gas, has now attracted attention as one of the gasotransmitters involved in many reactions in the human body. H<sub>2</sub>S has been assumed to play a role in the pathogenesis of many chronic diseases, of which the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1570 |
| _version_ | 1797585690769227776 |
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| author | Nathalie Stummer René G. Feichtinger Daniel Weghuber Barbara Kofler Anna M. Schneider |
| author_facet | Nathalie Stummer René G. Feichtinger Daniel Weghuber Barbara Kofler Anna M. Schneider |
| author_sort | Nathalie Stummer |
| collection | DOAJ |
| description | Hydrogen sulfide (H<sub>2</sub>S), originally known as toxic gas, has now attracted attention as one of the gasotransmitters involved in many reactions in the human body. H<sub>2</sub>S has been assumed to play a role in the pathogenesis of many chronic diseases, of which the exact pathogenesis remains unknown. One of them is inflammatory bowel disease (IBD), a chronic intestinal disease subclassified as Crohn’s disease (CD) and ulcerative colitis (UC). Any change in the amount of H<sub>2</sub>S seems to be linked to inflammation in this illness. These changes can be brought about by alterations in the microbiota, in the endogenous metabolism of H<sub>2</sub>S and in the diet. As both too little and too much H<sub>2</sub>S drive inflammation, a balanced level is needed for intestinal health. The aim of this review is to summarize the available literature published until June 2023 in order to provide an overview of the current knowledge of the connection between H<sub>2</sub>S and IBD. |
| first_indexed | 2024-03-11T00:10:39Z |
| format | Article |
| id | doaj.art-832e5c7dd14e4721a838c4487731f4cd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:39Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-832e5c7dd14e4721a838c4487731f4cd2023-11-19T00:02:02ZengMDPI AGAntioxidants2076-39212023-08-01128157010.3390/antiox12081570Role of Hydrogen Sulfide in Inflammatory Bowel DiseaseNathalie Stummer0René G. Feichtinger1Daniel Weghuber2Barbara Kofler3Anna M. Schneider4Department of Pediatrics, University Hospital of the Paracelsus Medical University, 5020 Salzburg, AustriaDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, 5020 Salzburg, AustriaDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, 5020 Salzburg, AustriaDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, 5020 Salzburg, AustriaDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, 5020 Salzburg, AustriaHydrogen sulfide (H<sub>2</sub>S), originally known as toxic gas, has now attracted attention as one of the gasotransmitters involved in many reactions in the human body. H<sub>2</sub>S has been assumed to play a role in the pathogenesis of many chronic diseases, of which the exact pathogenesis remains unknown. One of them is inflammatory bowel disease (IBD), a chronic intestinal disease subclassified as Crohn’s disease (CD) and ulcerative colitis (UC). Any change in the amount of H<sub>2</sub>S seems to be linked to inflammation in this illness. These changes can be brought about by alterations in the microbiota, in the endogenous metabolism of H<sub>2</sub>S and in the diet. As both too little and too much H<sub>2</sub>S drive inflammation, a balanced level is needed for intestinal health. The aim of this review is to summarize the available literature published until June 2023 in order to provide an overview of the current knowledge of the connection between H<sub>2</sub>S and IBD.https://www.mdpi.com/2076-3921/12/8/1570hydrogen sulfide (H<sub>2</sub>S)inflammatory bowel disease (IBD)Crohn’s disease (CD)ulcerative colitis (UC) |
| spellingShingle | Nathalie Stummer René G. Feichtinger Daniel Weghuber Barbara Kofler Anna M. Schneider Role of Hydrogen Sulfide in Inflammatory Bowel Disease Antioxidants hydrogen sulfide (H<sub>2</sub>S) inflammatory bowel disease (IBD) Crohn’s disease (CD) ulcerative colitis (UC) |
| title | Role of Hydrogen Sulfide in Inflammatory Bowel Disease |
| title_full | Role of Hydrogen Sulfide in Inflammatory Bowel Disease |
| title_fullStr | Role of Hydrogen Sulfide in Inflammatory Bowel Disease |
| title_full_unstemmed | Role of Hydrogen Sulfide in Inflammatory Bowel Disease |
| title_short | Role of Hydrogen Sulfide in Inflammatory Bowel Disease |
| title_sort | role of hydrogen sulfide in inflammatory bowel disease |
| topic | hydrogen sulfide (H<sub>2</sub>S) inflammatory bowel disease (IBD) Crohn’s disease (CD) ulcerative colitis (UC) |
| url | https://www.mdpi.com/2076-3921/12/8/1570 |
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