Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis
PurposeAuditory verbal hallucinations (AVH) are among the most common and prominent symptoms of schizophrenia. Although abnormal functional connectivity associated with AVH has been reported in multiple regions, the changes in information flow remain unclear. In this study, we aimed to elucidate cau...
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| Format: | Article |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00575/full |
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| author | Jie Gao Dongsheng Zhang Lei Wang Wei Wang Yajuan Fan Min Tang Xin Zhang Xiaoyan Lei Yarong Wang Jian Yang Xiaoling Zhang |
| author_facet | Jie Gao Dongsheng Zhang Lei Wang Wei Wang Yajuan Fan Min Tang Xin Zhang Xiaoyan Lei Yarong Wang Jian Yang Xiaoling Zhang |
| author_sort | Jie Gao |
| collection | DOAJ |
| description | PurposeAuditory verbal hallucinations (AVH) are among the most common and prominent symptoms of schizophrenia. Although abnormal functional connectivity associated with AVH has been reported in multiple regions, the changes in information flow remain unclear. In this study, we aimed to elucidate causal influences related to AVH in key regions of auditory, language, and memory networks, by using Granger causality analysis (GCA).Patients and MethodsEighteen patients with schizophrenia with AVH and eighteen matched patients without AVH who received resting-state fMRI scans were enrolled in the study. The bilateral superior temporal gyrus (STG), Broca’s area, Wernicke’s area, putamen, and hippocampus were selected as regions of interest.ResultsGranger causality (GC) increased from Broca’s area to the left STG, and decreased from the right homolog of Wernicke’s area to the right homolog of Broca’s area, and from the right STG to the right hippocampus in the AVH group compared with the non-AVH group. Correlation analysis showed that the normalized GC ratios from the left STG to Broca’s area, from the left STG to the right homolog of Broca’s area, and from the right STG to the right homolog of Broca’s area were negatively correlated with severity of AVH, and the normalized GC ratios from Broca’s area to the left hippocampus and from Broca’s area to the right STG were positively correlated with severity of AVH.ConclusionOur findings indicate a causal influence of pivotal regions involving the auditory, language, and memory networks in schizophrenia with AVH, which provide a deeper understanding of the neural mechanisms underlying AVH. |
| first_indexed | 2024-12-21T23:10:30Z |
| format | Article |
| id | doaj.art-833075731a394ad9aacf869ff8ee2e19 |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-21T23:10:30Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-833075731a394ad9aacf869ff8ee2e192022-12-21T18:47:02ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-06-011110.3389/fpsyt.2020.00575547275Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality AnalysisJie Gao0Dongsheng Zhang1Lei Wang2Wei Wang3Yajuan Fan4Min Tang5Xin Zhang6Xiaoyan Lei7Yarong Wang8Jian Yang9Xiaoling Zhang10Department of MRI, Shaanxi Provincial People’s Hospital, Xi’an, ChinaDepartment of MRI, Shaanxi Provincial People’s Hospital, Xi’an, ChinaDepartment of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of MRI, Shaanxi Provincial People’s Hospital, Xi’an, ChinaDepartment of MRI, Shaanxi Provincial People’s Hospital, Xi’an, ChinaDepartment of MRI, Shaanxi Provincial People’s Hospital, Xi’an, ChinaDepartment of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of MRI, Shaanxi Provincial People’s Hospital, Xi’an, ChinaPurposeAuditory verbal hallucinations (AVH) are among the most common and prominent symptoms of schizophrenia. Although abnormal functional connectivity associated with AVH has been reported in multiple regions, the changes in information flow remain unclear. In this study, we aimed to elucidate causal influences related to AVH in key regions of auditory, language, and memory networks, by using Granger causality analysis (GCA).Patients and MethodsEighteen patients with schizophrenia with AVH and eighteen matched patients without AVH who received resting-state fMRI scans were enrolled in the study. The bilateral superior temporal gyrus (STG), Broca’s area, Wernicke’s area, putamen, and hippocampus were selected as regions of interest.ResultsGranger causality (GC) increased from Broca’s area to the left STG, and decreased from the right homolog of Wernicke’s area to the right homolog of Broca’s area, and from the right STG to the right hippocampus in the AVH group compared with the non-AVH group. Correlation analysis showed that the normalized GC ratios from the left STG to Broca’s area, from the left STG to the right homolog of Broca’s area, and from the right STG to the right homolog of Broca’s area were negatively correlated with severity of AVH, and the normalized GC ratios from Broca’s area to the left hippocampus and from Broca’s area to the right STG were positively correlated with severity of AVH.ConclusionOur findings indicate a causal influence of pivotal regions involving the auditory, language, and memory networks in schizophrenia with AVH, which provide a deeper understanding of the neural mechanisms underlying AVH.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00575/fullschizophreniaauditory verbal hallucinationmagnetic resonance imagingresting stateeffective connectivity |
| spellingShingle | Jie Gao Dongsheng Zhang Lei Wang Wei Wang Yajuan Fan Min Tang Xin Zhang Xiaoyan Lei Yarong Wang Jian Yang Xiaoling Zhang Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis Frontiers in Psychiatry schizophrenia auditory verbal hallucination magnetic resonance imaging resting state effective connectivity |
| title | Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis |
| title_full | Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis |
| title_fullStr | Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis |
| title_full_unstemmed | Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis |
| title_short | Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis |
| title_sort | altered effective connectivity in schizophrenic patients with auditory verbal hallucinations a resting state fmri study with granger causality analysis |
| topic | schizophrenia auditory verbal hallucination magnetic resonance imaging resting state effective connectivity |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00575/full |
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