Evolutionary rewiring of bacterial regulatory networks
Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. The...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2015-07-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/evolutionary-rewiring-of-bacterial-regulatory-networks/ |
| _version_ | 1811344133830213632 |
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| author | Tiffany B. Taylor Geraldine Mulley Liam J. McGuffin Louise J. Johnson Michael A. Brockhurst Tanya Arseneault Mark W. Silby Robert W. Jackson |
| author_facet | Tiffany B. Taylor Geraldine Mulley Liam J. McGuffin Louise J. Johnson Michael A. Brockhurst Tanya Arseneault Mark W. Silby Robert W. Jackson |
| author_sort | Tiffany B. Taylor |
| collection | DOAJ |
| description | Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks – homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs. |
| first_indexed | 2024-04-13T19:42:20Z |
| format | Article |
| id | doaj.art-83317a3f7d4e499fac31047555daf89a |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2024-04-13T19:42:20Z |
| publishDate | 2015-07-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-83317a3f7d4e499fac31047555daf89a2022-12-22T02:32:51ZengShared Science Publishers OGMicrobial Cell2311-26382015-07-012725625810.15698/mic2015.07.215123455678Evolutionary rewiring of bacterial regulatory networksTiffany B. Taylor0Geraldine Mulley1Liam J. McGuffin2Louise J. Johnson3Michael A. Brockhurst4Tanya Arseneault5Mark W. Silby6Robert W. Jackson7School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.Department of Biology, University of York, Wentworth Way, York YO10 5DD, UK.School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.Department of Biology, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02747, USA.School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks – homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs.http://microbialcell.com/researcharticles/evolutionary-rewiring-of-bacterial-regulatory-networks/bacterial motilityflagella regulationnitrogen regulationgene network evolutionenhancing binding proteins |
| spellingShingle | Tiffany B. Taylor Geraldine Mulley Liam J. McGuffin Louise J. Johnson Michael A. Brockhurst Tanya Arseneault Mark W. Silby Robert W. Jackson Evolutionary rewiring of bacterial regulatory networks Microbial Cell bacterial motility flagella regulation nitrogen regulation gene network evolution enhancing binding proteins |
| title | Evolutionary rewiring of bacterial regulatory networks |
| title_full | Evolutionary rewiring of bacterial regulatory networks |
| title_fullStr | Evolutionary rewiring of bacterial regulatory networks |
| title_full_unstemmed | Evolutionary rewiring of bacterial regulatory networks |
| title_short | Evolutionary rewiring of bacterial regulatory networks |
| title_sort | evolutionary rewiring of bacterial regulatory networks |
| topic | bacterial motility flagella regulation nitrogen regulation gene network evolution enhancing binding proteins |
| url | http://microbialcell.com/researcharticles/evolutionary-rewiring-of-bacterial-regulatory-networks/ |
| work_keys_str_mv | AT tiffanybtaylor evolutionaryrewiringofbacterialregulatorynetworks AT geraldinemulley evolutionaryrewiringofbacterialregulatorynetworks AT liamjmcguffin evolutionaryrewiringofbacterialregulatorynetworks AT louisejjohnson evolutionaryrewiringofbacterialregulatorynetworks AT michaelabrockhurst evolutionaryrewiringofbacterialregulatorynetworks AT tanyaarseneault evolutionaryrewiringofbacterialregulatorynetworks AT markwsilby evolutionaryrewiringofbacterialregulatorynetworks AT robertwjackson evolutionaryrewiringofbacterialregulatorynetworks |