Alemtuzumab-induced alopecia universalis and transient accommodation spasm in a patient with multiple sclerosis

Alemtuzumab-induced alopecia universalis and transient accommodation spasm in a patient with multiple sclerosis

Herein, we report a case of alopecia universalis and transient accommodation spasm presented after alemtuzumab administration in a patient previously treated with fingolimod. To the best of our knowledge, this is the first report of accommodation spasm as an acute adverse effect of alemtuzumab. Trea...

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Bibliographic Details
Main Authors: Dimitrios Tzanetakos, Marianthi Breza, John S. Tzartos, Georgios Bontzos, Aigli G. Vakrakou, Alexandros Dermentzoglou, Ilias Gkizis, Georgios Smoustopoulos, Maria-Eleptheria Evangelopoulos, Leonidas Stefanis, Costantinos Kilidireas
Format: Article
Language:English
Published: SAGE Publishing 2022-10-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/17562864221127476
Description
Summary:Herein, we report a case of alopecia universalis and transient accommodation spasm presented after alemtuzumab administration in a patient previously treated with fingolimod. To the best of our knowledge, this is the first report of accommodation spasm as an acute adverse effect of alemtuzumab. Treatment with alemtuzumab in relapsing-remitting multiple sclerosis has been identified as a risk factor for developing secondary autoimmunity within the follow-up period (peak 18–36 months from the first infusion) such as thyroid disorders. This case highlights the need for postmarketing surveillance and the significance of reporting rare side effects related to alemtuzumab; its high efficacy should be weighted with potentially severe adverse events when making a therapeutic decision. Further studies in larger cohorts are needed to elucidate pathomechanisms of alemtuzumab.
ISSN:1756-2864

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