Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients
This study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy. This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for <1 month (m) or...
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.649181/full |
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| author | Li-Ling Guo Li-Ling Guo Li-Ling Guo Li-Ling Guo Yan-qiao Chen Yan-qiao Chen Yan-qiao Chen Yan-qiao Chen Qiu-zhen Lin Qiu-zhen Lin Qiu-zhen Lin Qiu-zhen Lin Feng Tian Feng Tian Feng Tian Feng Tian Qun-Yan Xiang Qun-Yan Xiang Qun-Yan Xiang Qun-Yan Xiang Li-yuan Zhu Li-yuan Zhu Li-yuan Zhu Li-yuan Zhu Jin Xu Jin Xu Jin Xu Jin Xu Tie Wen Ling Liu Ling Liu Ling Liu Ling Liu |
| author_facet | Li-Ling Guo Li-Ling Guo Li-Ling Guo Li-Ling Guo Yan-qiao Chen Yan-qiao Chen Yan-qiao Chen Yan-qiao Chen Qiu-zhen Lin Qiu-zhen Lin Qiu-zhen Lin Qiu-zhen Lin Feng Tian Feng Tian Feng Tian Feng Tian Qun-Yan Xiang Qun-Yan Xiang Qun-Yan Xiang Qun-Yan Xiang Li-yuan Zhu Li-yuan Zhu Li-yuan Zhu Li-yuan Zhu Jin Xu Jin Xu Jin Xu Jin Xu Tie Wen Ling Liu Ling Liu Ling Liu Ling Liu |
| author_sort | Li-Ling Guo |
| collection | DOAJ |
| description | This study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy. This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for <1 month (m) or did not take any statin before admission (CHD1 group), while 204 patients took statins for ≥1 m before admission (CHD2 group). Blood lipid levels were measured at 0, 2, and 4 h after a daily breakfast. Non-fasting LDL-C and non-HDL-C levels significantly decreased after a daily meal (P < 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percentage attainment of LDL-C <1.4 mmol/L at 2 and 4 h after a daily breakfast was significantly higher than that during fasting (P < 0.05), but the percent attainment of non-fasting non-HDL-C <2.2 mmol/L was close to its fasting value (P > 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.19 and 2.11 mmol/L, corresponding to their fasting goal levels of 1.4 and 2.2 mmol/L, respectively. When post-prandial LDL-C and non-HDL-C goal attainments were re-evaluated using non-fasting cut-off points, there were no significant differences in percentage attainment between fasting and non-fasting states. Non-HDL-C is more stable than LDL-C in assessing the percent attainment of non-fasting lipid for coronary heart disease patients. If we want to use LDL-C to assess the percent attainment of post-prandial blood lipids, we may need to determine a lower non-fasting cut-off point. |
| first_indexed | 2024-12-17T23:58:50Z |
| format | Article |
| id | doaj.art-83375f304cf04ee3bb586b177279fa10 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-17T23:58:50Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-83375f304cf04ee3bb586b177279fa102022-12-21T21:28:00ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-04-01810.3389/fcvm.2021.649181649181Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease PatientsLi-Ling Guo0Li-Ling Guo1Li-Ling Guo2Li-Ling Guo3Yan-qiao Chen4Yan-qiao Chen5Yan-qiao Chen6Yan-qiao Chen7Qiu-zhen Lin8Qiu-zhen Lin9Qiu-zhen Lin10Qiu-zhen Lin11Feng Tian12Feng Tian13Feng Tian14Feng Tian15Qun-Yan Xiang16Qun-Yan Xiang17Qun-Yan Xiang18Qun-Yan Xiang19Li-yuan Zhu20Li-yuan Zhu21Li-yuan Zhu22Li-yuan Zhu23Jin Xu24Jin Xu25Jin Xu26Jin Xu27Tie Wen28Ling Liu29Ling Liu30Ling Liu31Ling Liu32Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaDepartment of Emergency, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Institute of Blood Lipid and Atherosclerosis, Center South University, Changsha, ChinaModern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, Changsha, ChinaCardiovascular Disease Research Center of Hunan Province, Changsha, ChinaThis study aimed to compare the percentage attainment of fasting and non-fasting LDL-C and non-HDL-C target levels in coronary heart disease (CHD) patients receiving short-term statin therapy. This study enrolled 397 inpatients with CHD. Of these, 197 patients took statins for <1 month (m) or did not take any statin before admission (CHD1 group), while 204 patients took statins for ≥1 m before admission (CHD2 group). Blood lipid levels were measured at 0, 2, and 4 h after a daily breakfast. Non-fasting LDL-C and non-HDL-C levels significantly decreased after a daily meal (P < 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percentage attainment of LDL-C <1.4 mmol/L at 2 and 4 h after a daily breakfast was significantly higher than that during fasting (P < 0.05), but the percent attainment of non-fasting non-HDL-C <2.2 mmol/L was close to its fasting value (P > 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.19 and 2.11 mmol/L, corresponding to their fasting goal levels of 1.4 and 2.2 mmol/L, respectively. When post-prandial LDL-C and non-HDL-C goal attainments were re-evaluated using non-fasting cut-off points, there were no significant differences in percentage attainment between fasting and non-fasting states. Non-HDL-C is more stable than LDL-C in assessing the percent attainment of non-fasting lipid for coronary heart disease patients. If we want to use LDL-C to assess the percent attainment of post-prandial blood lipids, we may need to determine a lower non-fasting cut-off point.https://www.frontiersin.org/articles/10.3389/fcvm.2021.649181/fullcoronary heart diseasenon-fastinglow-density lipoprotein cholesterolnon-high-density lipoprotein cholesterolcut-off points |
| spellingShingle | Li-Ling Guo Li-Ling Guo Li-Ling Guo Li-Ling Guo Yan-qiao Chen Yan-qiao Chen Yan-qiao Chen Yan-qiao Chen Qiu-zhen Lin Qiu-zhen Lin Qiu-zhen Lin Qiu-zhen Lin Feng Tian Feng Tian Feng Tian Feng Tian Qun-Yan Xiang Qun-Yan Xiang Qun-Yan Xiang Qun-Yan Xiang Li-yuan Zhu Li-yuan Zhu Li-yuan Zhu Li-yuan Zhu Jin Xu Jin Xu Jin Xu Jin Xu Tie Wen Ling Liu Ling Liu Ling Liu Ling Liu Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients Frontiers in Cardiovascular Medicine coronary heart disease non-fasting low-density lipoprotein cholesterol non-high-density lipoprotein cholesterol cut-off points |
| title | Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients |
| title_full | Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients |
| title_fullStr | Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients |
| title_full_unstemmed | Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients |
| title_short | Non-HDL-C Is More Stable Than LDL-C in Assessing the Percent Attainment of Non-fasting Lipid for Coronary Heart Disease Patients |
| title_sort | non hdl c is more stable than ldl c in assessing the percent attainment of non fasting lipid for coronary heart disease patients |
| topic | coronary heart disease non-fasting low-density lipoprotein cholesterol non-high-density lipoprotein cholesterol cut-off points |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.649181/full |
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