Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bispecific constructs. Tetravalent bispecific tandem i...

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Bibliographic Details
Main Authors: Tuan-Minh Do, Cécile Capdevila, Laurent Pradier, Véronique Blanchard, Mati Lopez-Grancha, Nathalie Schussler, Anke Steinmetz, Jochen Beninga, Denis Boulay, Philippe Dugay, Patrick Verdier, Nadine Aubin, Gihad Dargazanli, Catarina Chaves, Elisabeth Genet, Yves Lossouarn, Christophe Loux, François Michoux, Nicolas Moindrot, Franck Chanut, Thierry Gury, Stéphanie Eyquem, Delphine Valente, Olivier Bergis, Ercole Rao, Dominique Lesuisse
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
brain delivery
bispecific antibodies
transferrin receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301807

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