In remembrance of commensal intestinal microbes
Mammals contain an enormous load of commensal microbes in the lower intestine, which induce adaptive responses in the host immune system that ensure mutual coexistence of the host and its microbial passengers. The main way of studying how the host responds to commensal colonization has been to compa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2010-11-01
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| Series: | Communicative & Integrative Biology |
| Online Access: | https://www.tandfonline.com/doi/10.4161/cib.3.6.13011 |
| _version_ | 1797683812439687168 |
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| author | Siegfried Hapfelmeier Andrew J. Macpherson |
| author_facet | Siegfried Hapfelmeier Andrew J. Macpherson |
| author_sort | Siegfried Hapfelmeier |
| collection | DOAJ |
| description | Mammals contain an enormous load of commensal microbes in the lower intestine, which induce adaptive responses in the host immune system that ensure mutual coexistence of the host and its microbial passengers. The main way of studying how the host responds to commensal colonization has been to compare animals kept in entirely germ-free conditions and their colonized counterparts. We present an overview of our development of a reversible colonization system, whereby germ free animals can be treated with live commensal bacteria that do not persist in the host, so it becomes germ free again. We describe how this system has been used to demonstrate that there is little or no immune memory for specific IgA induction in the intestinal mucosal immune system by commensal intestinal bacteria. |
| first_indexed | 2024-03-12T00:21:14Z |
| format | Article |
| id | doaj.art-8338b7cec33642d5b78266bac55aaceb |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-03-12T00:21:14Z |
| publishDate | 2010-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-8338b7cec33642d5b78266bac55aaceb2023-09-15T13:06:45ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892010-11-013656957110.4161/cib.3.6.13011In remembrance of commensal intestinal microbesSiegfried Hapfelmeier0Andrew J. Macpherson1DKF Maurice Mueller Laboratories, UVCM Inselspital, University of Bern, SwitzerlandDKF Maurice Mueller Laboratories, UVCM Inselspital, University of Bern, SwitzerlandMammals contain an enormous load of commensal microbes in the lower intestine, which induce adaptive responses in the host immune system that ensure mutual coexistence of the host and its microbial passengers. The main way of studying how the host responds to commensal colonization has been to compare animals kept in entirely germ-free conditions and their colonized counterparts. We present an overview of our development of a reversible colonization system, whereby germ free animals can be treated with live commensal bacteria that do not persist in the host, so it becomes germ free again. We describe how this system has been used to demonstrate that there is little or no immune memory for specific IgA induction in the intestinal mucosal immune system by commensal intestinal bacteria.https://www.tandfonline.com/doi/10.4161/cib.3.6.13011 |
| spellingShingle | Siegfried Hapfelmeier Andrew J. Macpherson In remembrance of commensal intestinal microbes Communicative & Integrative Biology |
| title | In remembrance of commensal intestinal microbes |
| title_full | In remembrance of commensal intestinal microbes |
| title_fullStr | In remembrance of commensal intestinal microbes |
| title_full_unstemmed | In remembrance of commensal intestinal microbes |
| title_short | In remembrance of commensal intestinal microbes |
| title_sort | in remembrance of commensal intestinal microbes |
| url | https://www.tandfonline.com/doi/10.4161/cib.3.6.13011 |
| work_keys_str_mv | AT siegfriedhapfelmeier inremembranceofcommensalintestinalmicrobes AT andrewjmacpherson inremembranceofcommensalintestinalmicrobes |