Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine

Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine

Non-small-cell lung cancers (NSCLC) represent 85% of all lung cancers, with adenocarcinoma as the most common subtype. Since the 2000's, the discovery of molecular alterations including epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements togethe...

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Bibliographic Details
Main Authors: Julian Pinsolle, Anne McLeer-Florin, Matteo Giaj Levra, Florence de Fraipont, Camille Emprou, Elisa Gobbini, Anne-Claire Toffart
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Medicine
Subjects:
non-small-cell lung cancer
molecular alterations
next-generation sequencing
liquid biopsy
ALK rearrangement
EGFR mutation
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00233/full

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