Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis
Objective: In the last 10 years, robotic platforms allowed to resume of some alternative surgical approaches, including perineal robot-assisted radical prostatectomy (p-RARP). Herein, we present in detail the oncological and functional outcomes of patients who underwent p-RARP with a median follow-u...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Asian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388223000826 |
| _version_ | 1827770240278200320 |
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| author | Umberto Carbonara Giuseppe Lippolis Luciano Rella Paolo Minafra Giuseppe Guglielmi Antonio Vitarelli Giuseppe Lucarelli Pasquale Ditonno |
| author_facet | Umberto Carbonara Giuseppe Lippolis Luciano Rella Paolo Minafra Giuseppe Guglielmi Antonio Vitarelli Giuseppe Lucarelli Pasquale Ditonno |
| author_sort | Umberto Carbonara |
| collection | DOAJ |
| description | Objective: In the last 10 years, robotic platforms allowed to resume of some alternative surgical approaches, including perineal robot-assisted radical prostatectomy (p-RARP). Herein, we present in detail the oncological and functional outcomes of patients who underwent p-RARP with a median follow-up of 30 months. Methods: Patients presenting low- or intermediate-risk prostate cancer and prostate volume up to 60 mL who underwent p-RARP between November 2018 and November 2022 were selected. Baseline, intraoperative, pathological, and postoperative data were collected and then analyzed. Results: Thirty-seven p-RARP cases were included. Such patients presented mean age of 62 years and a mean Charlson comorbidity index of 4. Body mass index of ≥25 kg/m2 was reported by 24 (64.9%) patients, as well as 7 (18.9%) patients reported a past surgical history. Mean prostate volume and median prostate-specific antigen were 41 mL and 6.2 ng/mL, respectively. The median operative time was 242 min. The positive surgical margin rate was 45.9%. In terms of postoperative complications, 10 patients reported complications with any grade; however, a single case (2.7%) of major (Clavien-Dindo grade ≥3) complication was observed. No patient with biochemical recurrence or distant metastasis was reported at 2 years of follow-up. Recovery of continence rates were 67.6%, 75.7%, and 92.9%, at 6 months, 12 months, and 24 months after surgery, respectively. Conclusion: p-RARP is a challenging but safe minimally invasive approach for selected patients with prostate cancer suitable for radical prostatectomy, showing outstanding functional recovery. Despite positive surgical margin rates being relatively high, no cases of biochemical recurrence or distant metastasis were reported after a median follow-up of 30 months. |
| first_indexed | 2024-03-11T12:35:45Z |
| format | Article |
| id | doaj.art-833981c1883e4f718e8c8525bfdd5ebb |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-03-11T12:35:45Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-833981c1883e4f718e8c8525bfdd5ebb2023-11-06T04:21:26ZengElsevierAsian Journal of Urology2214-38822023-10-01104423430Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysisUmberto Carbonara0Giuseppe Lippolis1Luciano Rella2Paolo Minafra3Giuseppe Guglielmi4Antonio Vitarelli5Giuseppe Lucarelli6Pasquale Ditonno7Corresponding author.; Department of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyDepartment of Emergency and Organ Transplantation, Urology Unit, Aldo Moro University, Bari, ItalyObjective: In the last 10 years, robotic platforms allowed to resume of some alternative surgical approaches, including perineal robot-assisted radical prostatectomy (p-RARP). Herein, we present in detail the oncological and functional outcomes of patients who underwent p-RARP with a median follow-up of 30 months. Methods: Patients presenting low- or intermediate-risk prostate cancer and prostate volume up to 60 mL who underwent p-RARP between November 2018 and November 2022 were selected. Baseline, intraoperative, pathological, and postoperative data were collected and then analyzed. Results: Thirty-seven p-RARP cases were included. Such patients presented mean age of 62 years and a mean Charlson comorbidity index of 4. Body mass index of ≥25 kg/m2 was reported by 24 (64.9%) patients, as well as 7 (18.9%) patients reported a past surgical history. Mean prostate volume and median prostate-specific antigen were 41 mL and 6.2 ng/mL, respectively. The median operative time was 242 min. The positive surgical margin rate was 45.9%. In terms of postoperative complications, 10 patients reported complications with any grade; however, a single case (2.7%) of major (Clavien-Dindo grade ≥3) complication was observed. No patient with biochemical recurrence or distant metastasis was reported at 2 years of follow-up. Recovery of continence rates were 67.6%, 75.7%, and 92.9%, at 6 months, 12 months, and 24 months after surgery, respectively. Conclusion: p-RARP is a challenging but safe minimally invasive approach for selected patients with prostate cancer suitable for radical prostatectomy, showing outstanding functional recovery. Despite positive surgical margin rates being relatively high, no cases of biochemical recurrence or distant metastasis were reported after a median follow-up of 30 months.http://www.sciencedirect.com/science/article/pii/S2214388223000826Prostate cancerRoboticPerinealRadical prostatectomyContinenceRobot-assisted radical prostatectomy |
| spellingShingle | Umberto Carbonara Giuseppe Lippolis Luciano Rella Paolo Minafra Giuseppe Guglielmi Antonio Vitarelli Giuseppe Lucarelli Pasquale Ditonno Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis Asian Journal of Urology Prostate cancer Robotic Perineal Radical prostatectomy Continence Robot-assisted radical prostatectomy |
| title | Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis |
| title_full | Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis |
| title_fullStr | Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis |
| title_full_unstemmed | Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis |
| title_short | Intermediate-term oncological and functional outcomes in prostate cancer patients treated with perineal robot-assisted radical prostatectomy: A single center analysis |
| title_sort | intermediate term oncological and functional outcomes in prostate cancer patients treated with perineal robot assisted radical prostatectomy a single center analysis |
| topic | Prostate cancer Robotic Perineal Radical prostatectomy Continence Robot-assisted radical prostatectomy |
| url | http://www.sciencedirect.com/science/article/pii/S2214388223000826 |
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