A single-center experience with pancreatic cystic neuroendocrine tumors
Abstract Background Pancreatic neuroendocrine tumors (PNET) are rare, with a significant malignant potential. This study aimed to determine outcomes of patients with resected PNETs according to the cystic component and confirm the accuracy of preoperative staging. Methods From 1997 to 2016, 106 pati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-020-01994-6 |
| _version_ | 1818841327051210752 |
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| author | Ange Khalil Jacques Ewald Ugo Marchese Aurélie Autret Jonathan Garnier Patricia Niccoli Gilles Piana Flora Poizat Marc Giovannini Jean-Robert Delpero Olivier Turrini |
| author_facet | Ange Khalil Jacques Ewald Ugo Marchese Aurélie Autret Jonathan Garnier Patricia Niccoli Gilles Piana Flora Poizat Marc Giovannini Jean-Robert Delpero Olivier Turrini |
| author_sort | Ange Khalil |
| collection | DOAJ |
| description | Abstract Background Pancreatic neuroendocrine tumors (PNET) are rare, with a significant malignant potential. This study aimed to determine outcomes of patients with resected PNETs according to the cystic component and confirm the accuracy of preoperative staging. Methods From 1997 to 2016, 106 patients underwent resection of PNETs, including 73 purely solid (S-PNETs, 69%), 21 mixed (M-PNETs, 20%), and 12 purely cystic lesions (C-PNETs, 11%). To ensure consistent comparisons of overall (OS) and disease-free (DFS) survival outcomes between the 3 groups, the patients were matched according to the World Health Organization (WHO) grade and tumor height. Results Overall, the rate of correlation between the preoperative and pathological diagnoses was low in the C-PNET group (33%, P = 0.03). None of the 24 patients (23%) with metastatic disease at the time of surgery were in the C-PNET group. Furthermore, significantly more parenchyma-sparing resections (P = 0.039) and fewer enlarged resections (P = 0.019) were achieved in the C-PNET group. C-PNET group had a significantly lower node invasion rate than the S-PNET and M-PNET groups (8% vs. 41% and 24%, P = 0.004). Although median OS was comparable in all 3 groups before (P = 0.3) and after (P = 0.18) matching, higher median DFS was observed in the C-PNET group than in the other groups after matching (P = 0.038). Conclusion C-PNET was associated with a better prognosis than PNET with a solid component. The results support a wait-and-see policy in cases wherein a reliable preoperative diagnosis remains challenging. |
| first_indexed | 2024-12-19T04:24:19Z |
| format | Article |
| id | doaj.art-83399c94a15941da91ea34e2ce739dbb |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-19T04:24:19Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-83399c94a15941da91ea34e2ce739dbb2022-12-21T20:36:04ZengBMCWorld Journal of Surgical Oncology1477-78192020-08-011811810.1186/s12957-020-01994-6A single-center experience with pancreatic cystic neuroendocrine tumorsAnge Khalil0Jacques Ewald1Ugo Marchese2Aurélie Autret3Jonathan Garnier4Patricia Niccoli5Gilles Piana6Flora Poizat7Marc Giovannini8Jean-Robert Delpero9Olivier Turrini10Department of Surgery, ENETS co-E IPC NET Center, Institut Paoli-CalmettesDepartment of Surgery, ENETS co-E IPC NET Center, Institut Paoli-CalmettesDepartment of Surgery, ENETS co-E IPC NET Center, Institut Paoli-CalmettesDepartment of Biostatistics, Institut Paoli-CalmettesDepartment of Surgery, ENETS co-E IPC NET Center, Institut Paoli-CalmettesDepartment of Oncology, Institut Paoli-CalmettesDepartment of Radiology, Institut Paoli-CalmettesDepartment of Pathology, Institut Paoli-CalmettesDepartment of Endoscopy, Institut Paoli-CalmettesDepartment of Surgery, ENETS co-E IPC NET Center, Institut Paoli-CalmettesDepartment of Surgery, CNRS, Inserm, CRCM, Institut Paoli-Calmettes, Aix-Marseille UniversityAbstract Background Pancreatic neuroendocrine tumors (PNET) are rare, with a significant malignant potential. This study aimed to determine outcomes of patients with resected PNETs according to the cystic component and confirm the accuracy of preoperative staging. Methods From 1997 to 2016, 106 patients underwent resection of PNETs, including 73 purely solid (S-PNETs, 69%), 21 mixed (M-PNETs, 20%), and 12 purely cystic lesions (C-PNETs, 11%). To ensure consistent comparisons of overall (OS) and disease-free (DFS) survival outcomes between the 3 groups, the patients were matched according to the World Health Organization (WHO) grade and tumor height. Results Overall, the rate of correlation between the preoperative and pathological diagnoses was low in the C-PNET group (33%, P = 0.03). None of the 24 patients (23%) with metastatic disease at the time of surgery were in the C-PNET group. Furthermore, significantly more parenchyma-sparing resections (P = 0.039) and fewer enlarged resections (P = 0.019) were achieved in the C-PNET group. C-PNET group had a significantly lower node invasion rate than the S-PNET and M-PNET groups (8% vs. 41% and 24%, P = 0.004). Although median OS was comparable in all 3 groups before (P = 0.3) and after (P = 0.18) matching, higher median DFS was observed in the C-PNET group than in the other groups after matching (P = 0.038). Conclusion C-PNET was associated with a better prognosis than PNET with a solid component. The results support a wait-and-see policy in cases wherein a reliable preoperative diagnosis remains challenging.http://link.springer.com/article/10.1186/s12957-020-01994-6Pancreatic neuroendocrine tumorSurvivalCystic component |
| spellingShingle | Ange Khalil Jacques Ewald Ugo Marchese Aurélie Autret Jonathan Garnier Patricia Niccoli Gilles Piana Flora Poizat Marc Giovannini Jean-Robert Delpero Olivier Turrini A single-center experience with pancreatic cystic neuroendocrine tumors World Journal of Surgical Oncology Pancreatic neuroendocrine tumor Survival Cystic component |
| title | A single-center experience with pancreatic cystic neuroendocrine tumors |
| title_full | A single-center experience with pancreatic cystic neuroendocrine tumors |
| title_fullStr | A single-center experience with pancreatic cystic neuroendocrine tumors |
| title_full_unstemmed | A single-center experience with pancreatic cystic neuroendocrine tumors |
| title_short | A single-center experience with pancreatic cystic neuroendocrine tumors |
| title_sort | single center experience with pancreatic cystic neuroendocrine tumors |
| topic | Pancreatic neuroendocrine tumor Survival Cystic component |
| url | http://link.springer.com/article/10.1186/s12957-020-01994-6 |
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