Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction

Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction

Abstract Background The epididymis is crucial for post-testicular sperm development which is termed sperm maturation. During this process, fertilizing ability is acquired through the epididymis-sperm communication via exchange of protein and small non-coding RNAs (sncRNAs). More importantly, epididy...

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Bibliographic Details
Main Authors: Zhuoyao Ma, Jinyu Li, Li Fu, Rong Fu, Ningyuan Tang, Yanmei Quan, Zhixiang Xin, Zhide Ding, Yue Liu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Medicine
Subjects:
Astheno-teratozoospermia
Intergenerational metabolic inheritance
Small non-coding RNAs
Ribonuclease T2
Sperm maturation
Online Access:https://doi.org/10.1186/s12916-023-03158-1

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