What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease?
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. As the second stage of developing steatosis, nonalcoholic hepatitis (NASH) carries the risk of fibrosis, cirrhosis, and hepatocellular carcinoma. Sarcopenia is defined as a condition characterized by...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/1/37 |
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| author | Katarzyna Ferenc Sara Jarmakiewicz-Czaja Rafał Filip |
| author_facet | Katarzyna Ferenc Sara Jarmakiewicz-Czaja Rafał Filip |
| author_sort | Katarzyna Ferenc |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. As the second stage of developing steatosis, nonalcoholic hepatitis (NASH) carries the risk of fibrosis, cirrhosis, and hepatocellular carcinoma. Sarcopenia is defined as a condition characterized by a decrease in muscle mass and functional decline. Both NAFLD and sarcopenia are global problems. The pathophysiological mechanisms that link the two entities of the disease are insulin resistance, inflammation, nutritional deficiencies, impairment of myostatin and adiponectin, or physical inactivity. Furthermore, disorders of the gut-liver axis appear to induce the process of developing NAFLD and sarcopenia. The correlations between NAFLD and sarcopenia appear to be bidirectional, so the main objective of the review was to determine the cause-and-effect relationship between the two diseases. |
| first_indexed | 2024-03-08T10:44:26Z |
| format | Article |
| id | doaj.art-833b4fae51c54939be7c071386f3ac6a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T10:44:26Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-833b4fae51c54939be7c071386f3ac6a2024-01-26T17:20:31ZengMDPI AGLife2075-17292023-12-011413710.3390/life14010037What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease?Katarzyna Ferenc0Sara Jarmakiewicz-Czaja1Rafał Filip2Institute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, PolandInstitute of Health Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, PolandInstitute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, PolandNonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. As the second stage of developing steatosis, nonalcoholic hepatitis (NASH) carries the risk of fibrosis, cirrhosis, and hepatocellular carcinoma. Sarcopenia is defined as a condition characterized by a decrease in muscle mass and functional decline. Both NAFLD and sarcopenia are global problems. The pathophysiological mechanisms that link the two entities of the disease are insulin resistance, inflammation, nutritional deficiencies, impairment of myostatin and adiponectin, or physical inactivity. Furthermore, disorders of the gut-liver axis appear to induce the process of developing NAFLD and sarcopenia. The correlations between NAFLD and sarcopenia appear to be bidirectional, so the main objective of the review was to determine the cause-and-effect relationship between the two diseases.https://www.mdpi.com/2075-1729/14/1/37fatty liverinflammationinsulin resistancesarcopenia |
| spellingShingle | Katarzyna Ferenc Sara Jarmakiewicz-Czaja Rafał Filip What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease? Life fatty liver inflammation insulin resistance sarcopenia |
| title | What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease? |
| title_full | What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease? |
| title_fullStr | What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease? |
| title_full_unstemmed | What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease? |
| title_short | What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease? |
| title_sort | what does sarcopenia have to do with nonalcoholic fatty liver disease |
| topic | fatty liver inflammation insulin resistance sarcopenia |
| url | https://www.mdpi.com/2075-1729/14/1/37 |
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