<i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance
<i>Salmonella enterica</i> subsp. <i>enterica</i> serovar <i>Dublin</i> (<i>S.</i><i>Dublin</i>) is a cattle-adapted pathogen that has emerged as one of the most commonly isolated and multidrug resistant (MDR) serovars in cattle. <i>S...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/8/1110 |
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| author | Heather M. Fritz Richard V. Pereira Kathy Toohey-Kurth Edie Marshall Jenna Tucker Kristin A. Clothier |
| author_facet | Heather M. Fritz Richard V. Pereira Kathy Toohey-Kurth Edie Marshall Jenna Tucker Kristin A. Clothier |
| author_sort | Heather M. Fritz |
| collection | DOAJ |
| description | <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar <i>Dublin</i> (<i>S.</i><i>Dublin</i>) is a cattle-adapted pathogen that has emerged as one of the most commonly isolated and multidrug resistant (MDR) serovars in cattle. <i>S.</i><i>Dublin</i> may be shed in feces, milk, and colostrum and persist in asymptomatic cattle, leading to spread and outbreaks in herds. Though infections with <i>S.</i><i>Dublin</i> in humans are rare, they are frequently severe, with extraintestinal spread that requires hospitalization and antimicrobial therapy. To determine minimum inhibitory concentration (MIC) and antimicrobial resistance (AMR) patterns and trends in cattle in California, broth microdilution testing was performed on 247 clinical <i>S</i>. <i>Dublin</i> isolates recovered from cattle at the California Animal Health and Food Safety Laboratory System (CAHFS) over the last three decades (1993–2019). Mean MICs and classification of resistance to antimicrobial drugs using a clinical livestock panel and the National Antimicrobial Resistance Monitoring System (NARMS) Gram-negative drug panels were utilized to assess prevalence and trends in AMR. Findings indicate an increase in AMR for the years 1993 to 2015. Notably, compared to the baseline year interval (1993–1999), there was an increase in resistance among quinolone and cephalosporin drugs, as well as an increased number of isolates with an MDR profile. |
| first_indexed | 2024-03-09T10:02:36Z |
| format | Article |
| id | doaj.art-8341df3c257d49389dc275a2f4de6268 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T10:02:36Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8341df3c257d49389dc275a2f4de62682023-12-01T23:19:46ZengMDPI AGAntibiotics2079-63822022-08-01118111010.3390/antibiotics11081110<i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical RelevanceHeather M. Fritz0Richard V. Pereira1Kathy Toohey-Kurth2Edie Marshall3Jenna Tucker4Kristin A. Clothier5California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USADepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USACalifornia Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, San Bernadino, CA 92411, USACalifornia Department of Food and Agriculture, Antimicrobial Use and Stewardship, Sacramento, CA 95814, USACalifornia Department of Food and Agriculture, Antimicrobial Use and Stewardship, Sacramento, CA 95814, USACalifornia Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA<i>Salmonella enterica</i> subsp. <i>enterica</i> serovar <i>Dublin</i> (<i>S.</i><i>Dublin</i>) is a cattle-adapted pathogen that has emerged as one of the most commonly isolated and multidrug resistant (MDR) serovars in cattle. <i>S.</i><i>Dublin</i> may be shed in feces, milk, and colostrum and persist in asymptomatic cattle, leading to spread and outbreaks in herds. Though infections with <i>S.</i><i>Dublin</i> in humans are rare, they are frequently severe, with extraintestinal spread that requires hospitalization and antimicrobial therapy. To determine minimum inhibitory concentration (MIC) and antimicrobial resistance (AMR) patterns and trends in cattle in California, broth microdilution testing was performed on 247 clinical <i>S</i>. <i>Dublin</i> isolates recovered from cattle at the California Animal Health and Food Safety Laboratory System (CAHFS) over the last three decades (1993–2019). Mean MICs and classification of resistance to antimicrobial drugs using a clinical livestock panel and the National Antimicrobial Resistance Monitoring System (NARMS) Gram-negative drug panels were utilized to assess prevalence and trends in AMR. Findings indicate an increase in AMR for the years 1993 to 2015. Notably, compared to the baseline year interval (1993–1999), there was an increase in resistance among quinolone and cephalosporin drugs, as well as an increased number of isolates with an MDR profile.https://www.mdpi.com/2079-6382/11/8/1110<i>Salmonella enterica</i> serovar <i>Dublin</i>cattleantimicrobial resistancetrendsantimicrobial susceptibility testingMIC |
| spellingShingle | Heather M. Fritz Richard V. Pereira Kathy Toohey-Kurth Edie Marshall Jenna Tucker Kristin A. Clothier <i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance Antibiotics <i>Salmonella enterica</i> serovar <i>Dublin</i> cattle antimicrobial resistance trends antimicrobial susceptibility testing MIC |
| title | <i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance |
| title_full | <i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance |
| title_fullStr | <i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance |
| title_full_unstemmed | <i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance |
| title_short | <i>Salmonella enterica</i> Serovar <i>Dublin</i> from Cattle in California from 1993–2019: Antimicrobial Resistance Trends of Clinical Relevance |
| title_sort | i salmonella enterica i serovar i dublin i from cattle in california from 1993 2019 antimicrobial resistance trends of clinical relevance |
| topic | <i>Salmonella enterica</i> serovar <i>Dublin</i> cattle antimicrobial resistance trends antimicrobial susceptibility testing MIC |
| url | https://www.mdpi.com/2079-6382/11/8/1110 |
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