Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics
Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function i...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/8/1760 |
| _version_ | 1797537262081146880 |
|---|---|
| author | Adrien Flahault Gabriel Altit Aurélie Sonea Anne-Sophie Gervais Muhammad Oneeb Rehman Mian Rong Wu Eva Desbrousses Ly Mai Anik Cloutier Jessica Simoneau Anie Lapointe Andréanne Villeneuve Patrick Garceau Michel White Jean-Luc Bigras Thuy Mai Luu Anne Monique Nuyt |
| author_facet | Adrien Flahault Gabriel Altit Aurélie Sonea Anne-Sophie Gervais Muhammad Oneeb Rehman Mian Rong Wu Eva Desbrousses Ly Mai Anik Cloutier Jessica Simoneau Anie Lapointe Andréanne Villeneuve Patrick Garceau Michel White Jean-Luc Bigras Thuy Mai Luu Anne Monique Nuyt |
| author_sort | Adrien Flahault |
| collection | DOAJ |
| description | Preterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e’ wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population. |
| first_indexed | 2024-03-10T12:12:38Z |
| format | Article |
| id | doaj.art-83428b18875245ed83a2e1c5a225ce6b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:12:38Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-83428b18875245ed83a2e1c5a225ce6b2023-11-21T16:04:16ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01108176010.3390/jcm10081760Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal CharacteristicsAdrien Flahault0Gabriel Altit1Aurélie Sonea2Anne-Sophie Gervais3Muhammad Oneeb Rehman Mian4Rong Wu5Eva Desbrousses6Ly Mai7Anik Cloutier8Jessica Simoneau9Anie Lapointe10Andréanne Villeneuve11Patrick Garceau12Michel White13Jean-Luc Bigras14Thuy Mai Luu15Anne Monique Nuyt16Sainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaDivision of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaDivision of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, QC H3T 1C5, CanadaDepartment of Pediatrics, Sainte-Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaDepartment of Pediatrics, Sainte-Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaDepartment of Medicine, Montreal Heart Institute, Faculty of Medicine, University of Montreal, Montreal, QC H1T 1C8, CanadaDepartment of Medicine, Montreal Heart Institute, Faculty of Medicine, University of Montreal, Montreal, QC H1T 1C8, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaSainte-Justine University Hospital Research Center Sainte, Justine University Hospital, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1C5, CanadaPreterm birth increases risk of cardiovascular disease and early death. A body of evidence suggests left ventricle (LV) echocardiographic alterations in children and adults born preterm. We aimed to determine if neonatal characteristics were associated with alterations in LV structure and function in preterm adults. We evaluated a cohort of 86 young adults born preterm below 30 weeks of gestation, and 85 full-term controls. We determined LV dimensions and function using tissue Doppler imaging, conventional and speckle tracking echocardiography (STE). Adults born preterm had smaller LV dimensions, but these differences did not remain after adjustment for body surface area (BSA), which was smaller in the preterm group. Stroke volume and cardiac output were reduced even after adjustment for BSA. We found a smaller e’ wave in the preterm group, but other markers of systolic and diastolic function did not differ. Use of antenatal steroids may be associated with a further reduced cardiac output in those born preterm. Adults born preterm show alterations in markers of LV dimensions and function. Identification of these markers may represent opportunities for early prevention of cardiovascular events in this at-risk population.https://www.mdpi.com/2077-0383/10/8/1760preterm birthleft ventricleechocardiography |
| spellingShingle | Adrien Flahault Gabriel Altit Aurélie Sonea Anne-Sophie Gervais Muhammad Oneeb Rehman Mian Rong Wu Eva Desbrousses Ly Mai Anik Cloutier Jessica Simoneau Anie Lapointe Andréanne Villeneuve Patrick Garceau Michel White Jean-Luc Bigras Thuy Mai Luu Anne Monique Nuyt Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics Journal of Clinical Medicine preterm birth left ventricle echocardiography |
| title | Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics |
| title_full | Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics |
| title_fullStr | Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics |
| title_full_unstemmed | Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics |
| title_short | Left Ventricle Structure and Function in Young Adults Born Very Preterm and Association with Neonatal Characteristics |
| title_sort | left ventricle structure and function in young adults born very preterm and association with neonatal characteristics |
| topic | preterm birth left ventricle echocardiography |
| url | https://www.mdpi.com/2077-0383/10/8/1760 |
| work_keys_str_mv | AT adrienflahault leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT gabrielaltit leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT aureliesonea leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT annesophiegervais leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT muhammadoneebrehmanmian leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT rongwu leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT evadesbrousses leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT lymai leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT anikcloutier leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT jessicasimoneau leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT anielapointe leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT andreannevilleneuve leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT patrickgarceau leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT michelwhite leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT jeanlucbigras leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT thuymailuu leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics AT annemoniquenuyt leftventriclestructureandfunctioninyoungadultsbornverypretermandassociationwithneonatalcharacteristics |