Vaccine approaches conferring cross-protection against influenza viruses
Introduction: Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of the currently available influenza vaccines are strong inducers of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (N...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1379396 |
| _version_ | 1797680427205394432 |
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| author | Sai V Vemula Ekramy E Sayedahmed Suryaprakash Sambhara Suresh K Mittal |
| author_facet | Sai V Vemula Ekramy E Sayedahmed Suryaprakash Sambhara Suresh K Mittal |
| author_sort | Sai V Vemula |
| collection | DOAJ |
| description | Introduction: Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of the currently available influenza vaccines are strong inducers of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (NA), but are poor inducers of cell-mediated immune responses against conserved internal proteins. Moreover, due to the high variability of viral surface proteins because of antigenic drift or antigenic shift, many of the currently licensed vaccines confer little or no protection against drift or shift variants. Areas covered: Next generation influenza vaccines that can induce humoral immune responses to receptor-binding epitopes as well as broadly neutralizing conserved epitopes, and cell-mediated immune responses against highly conserved internal proteins would be effective against variant viruses as well as a novel pandemic influenza until circulating strain-specific vaccines become available. Here we discuss vaccine approaches that have the potential to provide broad spectrum protection against influenza viruses. Expert commentary: Based on current progress in defining cross-protective influenza immunity, it seems that the development of a universal influenza vaccine is feasible. It would revolutionize the strategy for influenza pandemic preparedness, and significantly impact the shelf-life and protection efficacy of seasonal influenza vaccines. |
| first_indexed | 2024-03-11T23:29:52Z |
| format | Article |
| id | doaj.art-83447cefbaf74fb781a420462a15a75a |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:52Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-83447cefbaf74fb781a420462a15a75a2023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-11-0116111141115410.1080/14760584.2017.13793961379396Vaccine approaches conferring cross-protection against influenza virusesSai V Vemula0Ekramy E Sayedahmed1Suryaprakash Sambhara2Suresh K Mittal3Inflammation and Infectious Disease, Purdue UniversityInflammation and Infectious Disease, Purdue UniversityCenters for Disease Control and PreventionInflammation and Infectious Disease, Purdue UniversityIntroduction: Annual vaccination is one of the most efficient and cost-effective strategies to prevent and control influenza epidemics. Most of the currently available influenza vaccines are strong inducers of antibody responses against viral surface proteins, hemagglutinin (HA) and neuraminidase (NA), but are poor inducers of cell-mediated immune responses against conserved internal proteins. Moreover, due to the high variability of viral surface proteins because of antigenic drift or antigenic shift, many of the currently licensed vaccines confer little or no protection against drift or shift variants. Areas covered: Next generation influenza vaccines that can induce humoral immune responses to receptor-binding epitopes as well as broadly neutralizing conserved epitopes, and cell-mediated immune responses against highly conserved internal proteins would be effective against variant viruses as well as a novel pandemic influenza until circulating strain-specific vaccines become available. Here we discuss vaccine approaches that have the potential to provide broad spectrum protection against influenza viruses. Expert commentary: Based on current progress in defining cross-protective influenza immunity, it seems that the development of a universal influenza vaccine is feasible. It would revolutionize the strategy for influenza pandemic preparedness, and significantly impact the shelf-life and protection efficacy of seasonal influenza vaccines.http://dx.doi.org/10.1080/14760584.2017.1379396influenza virusesnovel influenza vaccinescross protectionpandemic influenzauniversal influenza vaccinepandemic preparednessavian influenza viruses |
| spellingShingle | Sai V Vemula Ekramy E Sayedahmed Suryaprakash Sambhara Suresh K Mittal Vaccine approaches conferring cross-protection against influenza viruses Expert Review of Vaccines influenza viruses novel influenza vaccines cross protection pandemic influenza universal influenza vaccine pandemic preparedness avian influenza viruses |
| title | Vaccine approaches conferring cross-protection against influenza viruses |
| title_full | Vaccine approaches conferring cross-protection against influenza viruses |
| title_fullStr | Vaccine approaches conferring cross-protection against influenza viruses |
| title_full_unstemmed | Vaccine approaches conferring cross-protection against influenza viruses |
| title_short | Vaccine approaches conferring cross-protection against influenza viruses |
| title_sort | vaccine approaches conferring cross protection against influenza viruses |
| topic | influenza viruses novel influenza vaccines cross protection pandemic influenza universal influenza vaccine pandemic preparedness avian influenza viruses |
| url | http://dx.doi.org/10.1080/14760584.2017.1379396 |
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