Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1)
The study aimed to generate a local failure (LF) risk map in resected pancreatic cancer (PC) and validate the results of previous studies, proposing new guidelines for PC postoperative radiotherapy clinical target volume (CTV) delineation. Follow-up computer tomography (CT) of resected PC was retros...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/12/3051 |
| _version_ | 1797529576870510592 |
|---|---|
| author | Alessandra Arcelli Federica Bertini Silvia Strolin Gabriella Macchia Francesco Deodato Savino Cilla Salvatore Parisi Aldo Sainato Michele Fiore Pietro Gabriele Domenico Genovesi Francesco Cellini Alessandra Guido Silvia Cammelli Milly Buwenge Emiliano Loi Silvia Bisello Matteo Renzulli Rita Golfieri Alessio G. Morganti Lidia Strigari |
| author_facet | Alessandra Arcelli Federica Bertini Silvia Strolin Gabriella Macchia Francesco Deodato Savino Cilla Salvatore Parisi Aldo Sainato Michele Fiore Pietro Gabriele Domenico Genovesi Francesco Cellini Alessandra Guido Silvia Cammelli Milly Buwenge Emiliano Loi Silvia Bisello Matteo Renzulli Rita Golfieri Alessio G. Morganti Lidia Strigari |
| author_sort | Alessandra Arcelli |
| collection | DOAJ |
| description | The study aimed to generate a local failure (LF) risk map in resected pancreatic cancer (PC) and validate the results of previous studies, proposing new guidelines for PC postoperative radiotherapy clinical target volume (CTV) delineation. Follow-up computer tomography (CT) of resected PC was retrospectively reviewed by two radiologists identifying LFs and plotting them on a representative patient CT scan. The percentages of LF points randomly extracted based on CTV following the RTOG guidelines and based on the LF database were 70% and 30%, respectively. According to the Kernel density estimation, an LF 3D distribution map was generated and compared with the results of previous studies using a Dice index. Among the 64 resected patients, 59.4% underwent adjuvant treatment. LFs closer to the root of the celiac axis (CA) or the superior mesenteric artery (SMA) were reported in 32.8% and 67.2% cases, respectively. The mean (± standard deviation) distances of LF points to CA and SMA were 21.5 ± 17.9 mm and 21.6 ± 12.1 mm, respectively. The Dice values comparing our iso-level risk maps corresponding to 80% and 90% of the LF probabilistic density and the CTVs-80 and CTVs-90 of previous publications were 0.45–0.53 and 0.58–0.60, respectively. According to the Kernel density approach, a validated LF map was proposed, modeling a new adjuvant CTV based on a PC pattern of failure. |
| first_indexed | 2024-03-10T10:16:39Z |
| format | Article |
| id | doaj.art-8345191a8a024318b12f2c7d0e5c09a6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:16:39Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8345191a8a024318b12f2c7d0e5c09a62023-11-22T00:48:00ZengMDPI AGCancers2072-66942021-06-011312305110.3390/cancers13123051Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1)Alessandra Arcelli0Federica Bertini1Silvia Strolin2Gabriella Macchia3Francesco Deodato4Savino Cilla5Salvatore Parisi6Aldo Sainato7Michele Fiore8Pietro Gabriele9Domenico Genovesi10Francesco Cellini11Alessandra Guido12Silvia Cammelli13Milly Buwenge14Emiliano Loi15Silvia Bisello16Matteo Renzulli17Rita Golfieri18Alessio G. Morganti19Lidia Strigari20Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiation Oncology Unit, Gemelli Molise Hospital, Università Cattolica del Sacro Cuore, 86100 Campobasso, ItalyRadiation Oncology Unit, Gemelli Molise Hospital, Università Cattolica del Sacro Cuore, 86100 Campobasso, ItalyMedical Physics Unit, Gemelli Molise Hospital, Università Cattolica del Sacro Cuore, 86100 Campobasso, ItalyUnit of Radiation Therapy, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyRadiation Oncology, Pisa University Hospital, 56126 Pisa, ItalyRadiation Oncology, Campus Bio-Medico University, 00128 Rome, ItalyRadiation Therapy, Candiolo Cancer Institute–FPO, IRCCS Candiolo, 10060 Candiolo, ItalyDepartment of Radiation Oncology, SS. Annunziata Hospital, G. D’Annunzio University of Chieti, 66100 Chieti, ItalyIstituto di Radiologia, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyRadiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine–DIMES, Alma Mater Studiorum, Bologna University, 40138 Bologna, ItalyRadiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyMedical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyThe study aimed to generate a local failure (LF) risk map in resected pancreatic cancer (PC) and validate the results of previous studies, proposing new guidelines for PC postoperative radiotherapy clinical target volume (CTV) delineation. Follow-up computer tomography (CT) of resected PC was retrospectively reviewed by two radiologists identifying LFs and plotting them on a representative patient CT scan. The percentages of LF points randomly extracted based on CTV following the RTOG guidelines and based on the LF database were 70% and 30%, respectively. According to the Kernel density estimation, an LF 3D distribution map was generated and compared with the results of previous studies using a Dice index. Among the 64 resected patients, 59.4% underwent adjuvant treatment. LFs closer to the root of the celiac axis (CA) or the superior mesenteric artery (SMA) were reported in 32.8% and 67.2% cases, respectively. The mean (± standard deviation) distances of LF points to CA and SMA were 21.5 ± 17.9 mm and 21.6 ± 12.1 mm, respectively. The Dice values comparing our iso-level risk maps corresponding to 80% and 90% of the LF probabilistic density and the CTVs-80 and CTVs-90 of previous publications were 0.45–0.53 and 0.58–0.60, respectively. According to the Kernel density approach, a validated LF map was proposed, modeling a new adjuvant CTV based on a PC pattern of failure.https://www.mdpi.com/2072-6694/13/12/3051pancreatic neoplasmsadjuvant chemoradiationpattern of failureKernel density estimation |
| spellingShingle | Alessandra Arcelli Federica Bertini Silvia Strolin Gabriella Macchia Francesco Deodato Savino Cilla Salvatore Parisi Aldo Sainato Michele Fiore Pietro Gabriele Domenico Genovesi Francesco Cellini Alessandra Guido Silvia Cammelli Milly Buwenge Emiliano Loi Silvia Bisello Matteo Renzulli Rita Golfieri Alessio G. Morganti Lidia Strigari Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1) Cancers pancreatic neoplasms adjuvant chemoradiation pattern of failure Kernel density estimation |
| title | Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1) |
| title_full | Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1) |
| title_fullStr | Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1) |
| title_full_unstemmed | Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1) |
| title_short | Definition of Local Recurrence Site in Resected Pancreatic Adenocarcinoma: A Multicenter Study (DOLORES-1) |
| title_sort | definition of local recurrence site in resected pancreatic adenocarcinoma a multicenter study dolores 1 |
| topic | pancreatic neoplasms adjuvant chemoradiation pattern of failure Kernel density estimation |
| url | https://www.mdpi.com/2072-6694/13/12/3051 |
| work_keys_str_mv | AT alessandraarcelli definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT federicabertini definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT silviastrolin definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT gabriellamacchia definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT francescodeodato definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT savinocilla definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT salvatoreparisi definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT aldosainato definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT michelefiore definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT pietrogabriele definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT domenicogenovesi definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT francescocellini definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT alessandraguido definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT silviacammelli definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT millybuwenge definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT emilianoloi definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT silviabisello definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT matteorenzulli definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT ritagolfieri definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT alessiogmorganti definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 AT lidiastrigari definitionoflocalrecurrencesiteinresectedpancreaticadenocarcinomaamulticenterstudydolores1 |