Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI
Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume. Thirty-one female and 32 male genetic SVD (cerebral autos...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222003631 |
| _version_ | 1797869762756214784 |
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| author | Xiuqin Jia Chen Ling Yingying Li Jinyuan Zhang Zhixin Li Xuejia Jia Danny J.J. Wang Zihao Zhang Yun Yuan Qi Yang |
| author_facet | Xiuqin Jia Chen Ling Yingying Li Jinyuan Zhang Zhixin Li Xuejia Jia Danny J.J. Wang Zihao Zhang Yun Yuan Qi Yang |
| author_sort | Xiuqin Jia |
| collection | DOAJ |
| description | Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume. Thirty-one female and 32 male genetic SVD (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL) patients and 55 sex- and age-matched healthy controls (HCs) underwent 7-Tesla MRI examinations. Voxel-based W-score maps were calculated from volumes and deformations of brain tissues, controlling for the expected effects of age and sex in HCs. Significant cognitive declines in working memory and executive function were identified in male CADASIL patients compared to female patients. Greater gray matter (GM) atrophy was found in the bilateral orbitofrontal cortex (OFC), left anterior cingulate cortex (ACC), left entorhinal cortex (EC), and right temporooccipital cortex in male CADASIL patients than in females. Working memory was associated with volumes in the right OFC specific to female CADASIL patients, whereas visuospatial ability was associated with the right hOcl (primary visual area, BA 17) volume specific to males. The current findings indicate that sex affects the pathogenesis of CADASIL, ranging from differences in neuroanatomy to those in behavioral performance, which may facilitate the development of more effective sex-specific therapeutic strategies for CADASIL and SVD. |
| first_indexed | 2024-04-10T00:18:00Z |
| format | Article |
| id | doaj.art-8345524275044fbda4e3a443a65255bc |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-10T00:18:00Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-8345524275044fbda4e3a443a65255bc2023-03-16T05:03:57ZengElsevierNeuroImage: Clinical2213-15822023-01-0137103298Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRIXiuqin Jia0Chen Ling1Yingying Li2Jinyuan Zhang3Zhixin Li4Xuejia Jia5Danny J.J. Wang6Zihao Zhang7Yun Yuan8Qi Yang9Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, ChinaDepartment of Neurology, Peking University First Hospital, Beijing 100034, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaLab of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine of University of Southern California, Los Angeles, CA, USAState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China; Corresponding authors at: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China (Z. Zhang). Department of Neurology, Peking University First Hospital, No.8, Xishiku Street, Xicheng District, Beijing 100034, China (Y. Yuan). Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, No.8, Gongti South Road, Chaoyang District, Beijing 100020, China (Q. Yang).Department of Neurology, Peking University First Hospital, Beijing 100034, China; Corresponding authors at: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China (Z. Zhang). Department of Neurology, Peking University First Hospital, No.8, Xishiku Street, Xicheng District, Beijing 100034, China (Y. Yuan). Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, No.8, Gongti South Road, Chaoyang District, Beijing 100020, China (Q. Yang).Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China; Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, China; Corresponding authors at: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China (Z. Zhang). Department of Neurology, Peking University First Hospital, No.8, Xishiku Street, Xicheng District, Beijing 100034, China (Y. Yuan). Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, No.8, Gongti South Road, Chaoyang District, Beijing 100020, China (Q. Yang).Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume. Thirty-one female and 32 male genetic SVD (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL) patients and 55 sex- and age-matched healthy controls (HCs) underwent 7-Tesla MRI examinations. Voxel-based W-score maps were calculated from volumes and deformations of brain tissues, controlling for the expected effects of age and sex in HCs. Significant cognitive declines in working memory and executive function were identified in male CADASIL patients compared to female patients. Greater gray matter (GM) atrophy was found in the bilateral orbitofrontal cortex (OFC), left anterior cingulate cortex (ACC), left entorhinal cortex (EC), and right temporooccipital cortex in male CADASIL patients than in females. Working memory was associated with volumes in the right OFC specific to female CADASIL patients, whereas visuospatial ability was associated with the right hOcl (primary visual area, BA 17) volume specific to males. The current findings indicate that sex affects the pathogenesis of CADASIL, ranging from differences in neuroanatomy to those in behavioral performance, which may facilitate the development of more effective sex-specific therapeutic strategies for CADASIL and SVD.http://www.sciencedirect.com/science/article/pii/S2213158222003631Sex differencesFrontotemporal cortexCADASILSmall vessel disease |
| spellingShingle | Xiuqin Jia Chen Ling Yingying Li Jinyuan Zhang Zhixin Li Xuejia Jia Danny J.J. Wang Zihao Zhang Yun Yuan Qi Yang Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI NeuroImage: Clinical Sex differences Frontotemporal cortex CADASIL Small vessel disease |
| title | Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI |
| title_full | Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI |
| title_fullStr | Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI |
| title_full_unstemmed | Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI |
| title_short | Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI |
| title_sort | sex differences in frontotemporal atrophy in cadasil revealed by 7 tesla mri |
| topic | Sex differences Frontotemporal cortex CADASIL Small vessel disease |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222003631 |
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