The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset
Abstract Background Obesity is a risk factor for multiple myeloma (MM). However, we still lack knowledge on the clinical course of obese MM patients in a broad view. Methods Here, we reviewed 568 MM patients recorded in the Multiple Myeloma Research Foundation (MMRF) coMMpass dataset. Patients were...
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6685 |
| _version_ | 1797387126581493760 |
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| author | Liang Ren Tianhong Xu Yuhong Ren Peng Liu |
| author_facet | Liang Ren Tianhong Xu Yuhong Ren Peng Liu |
| author_sort | Liang Ren |
| collection | DOAJ |
| description | Abstract Background Obesity is a risk factor for multiple myeloma (MM). However, we still lack knowledge on the clinical course of obese MM patients in a broad view. Methods Here, we reviewed 568 MM patients recorded in the Multiple Myeloma Research Foundation (MMRF) coMMpass dataset. Patients were divided into the normal and obese groups according body mass index (BMI) at diagnosis, and then the baseline characteristics, cytogenetic abnormalities, treatment variability, and survival outcomes were evaluated in the obese cohort. Results We found no differences in the characteristics when comparing normal and obese MM patients other than more male in the obese part (50.4% vs. 59.9%, p = 0.024). Compared with the normal BMI patients, median overall survival (OS) was shorter for obese MM patients but without significant meaning (82.3 vs. 95.3 months, p = 0.25). However, in the subgroup analysis, obese MM patients younger than 65 years had significantly inferior OS than that in the normal category (p = 0.047). We also found obese MM patients had a higher overall response rate (ORR) compared with normal BMI patients (92.7% vs. 88.6%, p = 0.037). Additionally, obese patients seemed to achieve faster best response during first‐line therapy. Conclusions Obesity assumes a paradoxical function in the clinical trajectory of myeloma. |
| first_indexed | 2024-03-08T22:19:23Z |
| format | Article |
| id | doaj.art-83464b7edff442de9cb6209d08d17429 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-08T22:19:23Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-83464b7edff442de9cb6209d08d174292023-12-18T14:43:07ZengWileyCancer Medicine2045-76342023-12-011223214002140710.1002/cam4.6685The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) datasetLiang Ren0Tianhong Xu1Yuhong Ren2Peng Liu3Department of Hematology Zhongshan Hospital, Fudan University Shanghai P. R. ChinaDepartment of Hematology Zhongshan Hospital, Fudan University Shanghai P. R. ChinaDepartment of Hematology Zhongshan Hospital, Fudan University Shanghai P. R. ChinaDepartment of Hematology Zhongshan Hospital, Fudan University Shanghai P. R. ChinaAbstract Background Obesity is a risk factor for multiple myeloma (MM). However, we still lack knowledge on the clinical course of obese MM patients in a broad view. Methods Here, we reviewed 568 MM patients recorded in the Multiple Myeloma Research Foundation (MMRF) coMMpass dataset. Patients were divided into the normal and obese groups according body mass index (BMI) at diagnosis, and then the baseline characteristics, cytogenetic abnormalities, treatment variability, and survival outcomes were evaluated in the obese cohort. Results We found no differences in the characteristics when comparing normal and obese MM patients other than more male in the obese part (50.4% vs. 59.9%, p = 0.024). Compared with the normal BMI patients, median overall survival (OS) was shorter for obese MM patients but without significant meaning (82.3 vs. 95.3 months, p = 0.25). However, in the subgroup analysis, obese MM patients younger than 65 years had significantly inferior OS than that in the normal category (p = 0.047). We also found obese MM patients had a higher overall response rate (ORR) compared with normal BMI patients (92.7% vs. 88.6%, p = 0.037). Additionally, obese patients seemed to achieve faster best response during first‐line therapy. Conclusions Obesity assumes a paradoxical function in the clinical trajectory of myeloma.https://doi.org/10.1002/cam4.6685BMIcytogenetic abnormalmultiple myelomaobesity paradoxprognosis |
| spellingShingle | Liang Ren Tianhong Xu Yuhong Ren Peng Liu The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset Cancer Medicine BMI cytogenetic abnormal multiple myeloma obesity paradox prognosis |
| title | The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset |
| title_full | The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset |
| title_fullStr | The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset |
| title_full_unstemmed | The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset |
| title_short | The obesity paradox in multiple myeloma: A report from Multiple Myeloma Research Foundation (MMRF) dataset |
| title_sort | obesity paradox in multiple myeloma a report from multiple myeloma research foundation mmrf dataset |
| topic | BMI cytogenetic abnormal multiple myeloma obesity paradox prognosis |
| url | https://doi.org/10.1002/cam4.6685 |
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