A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study
Abstract Background Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4478-3 |
| _version_ | 1828183788096585728 |
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| author | Ersilia Lucenteforte Laura Vagnoli Alessandra Pugi Giada Crescioli Niccolò Lombardi Roberto Bonaiuti Maurizio Aricò Sabrina Giglio Andrea Messeri Alessandro Mugelli Alfredo Vannacci Valentina Maggini |
| author_facet | Ersilia Lucenteforte Laura Vagnoli Alessandra Pugi Giada Crescioli Niccolò Lombardi Roberto Bonaiuti Maurizio Aricò Sabrina Giglio Andrea Messeri Alessandro Mugelli Alfredo Vannacci Valentina Maggini |
| author_sort | Ersilia Lucenteforte |
| collection | DOAJ |
| description | Abstract Background Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients. Methods We conducted a systematic literature search in EMBASE and PubMed up to the 24th of November 2016 following Cochrane Handbook and PRISMA guidelines. Two independent reviewers screened titles and abstracts along with full-text papers; disagreements were resolved by discussion with two other independent reviewers. We used a data extraction form to provide details of the included studies, and conducted quality assessment using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Results Young age, lung or gastrointestinal cancer, neuropathic or breakthrough pain and anxiety or sleep disturbance were associated to a worse response to opioid analgesia. No clear association was identified in literature regarding gender, ethnicity, weight, presence of metastases, biochemical or hematological factors. Studies in children were lacking. Between June 2011 and April 2014, the Italian STOP Pain project enrolled 87 paediatric cancer patients under treatment with opioids (morphine, codeine, oxycodone, fentanyl and tramadol). Conclusions Future studies on cancer pain should be designed with consideration for the highlighted factors to enhance our understanding of opioid non-response and safety. Studies in children are mandatory. Trial registration CRD42017057740. |
| first_indexed | 2024-04-12T06:38:09Z |
| format | Article |
| id | doaj.art-8347b2da8b7c418aa5841510843d8adb |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T06:38:09Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-8347b2da8b7c418aa5841510843d8adb2022-12-22T03:43:48ZengBMCBMC Cancer1471-24072018-05-0118111210.1186/s12885-018-4478-3A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain studyErsilia Lucenteforte0Laura Vagnoli1Alessandra Pugi2Giada Crescioli3Niccolò Lombardi4Roberto Bonaiuti5Maurizio Aricò6Sabrina Giglio7Andrea Messeri8Alessandro Mugelli9Alfredo Vannacci10Valentina Maggini11Department of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorencePain and Palliative Care Unit, Meyer children’s hospitalClinical Trial Office, Meyer Children’s HospitalDepartment of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorenceDepartment of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorenceDepartment of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorenceDirezione Generale, Azienda Sanitaria ProvincialeMedical Genetics Unit, Meyer Children’s University HospitalPain and Palliative Care Unit, Meyer children’s hospitalDepartment of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorenceDepartment of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorenceDepartment of Neuroscience, Psychology, Drug Research and Children’s Health, University of FlorenceAbstract Background Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients. Methods We conducted a systematic literature search in EMBASE and PubMed up to the 24th of November 2016 following Cochrane Handbook and PRISMA guidelines. Two independent reviewers screened titles and abstracts along with full-text papers; disagreements were resolved by discussion with two other independent reviewers. We used a data extraction form to provide details of the included studies, and conducted quality assessment using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Results Young age, lung or gastrointestinal cancer, neuropathic or breakthrough pain and anxiety or sleep disturbance were associated to a worse response to opioid analgesia. No clear association was identified in literature regarding gender, ethnicity, weight, presence of metastases, biochemical or hematological factors. Studies in children were lacking. Between June 2011 and April 2014, the Italian STOP Pain project enrolled 87 paediatric cancer patients under treatment with opioids (morphine, codeine, oxycodone, fentanyl and tramadol). Conclusions Future studies on cancer pain should be designed with consideration for the highlighted factors to enhance our understanding of opioid non-response and safety. Studies in children are mandatory. Trial registration CRD42017057740.http://link.springer.com/article/10.1186/s12885-018-4478-3Cancer painChildrenOpioid efficacyOpioid safety |
| spellingShingle | Ersilia Lucenteforte Laura Vagnoli Alessandra Pugi Giada Crescioli Niccolò Lombardi Roberto Bonaiuti Maurizio Aricò Sabrina Giglio Andrea Messeri Alessandro Mugelli Alfredo Vannacci Valentina Maggini A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study BMC Cancer Cancer pain Children Opioid efficacy Opioid safety |
| title | A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study |
| title_full | A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study |
| title_fullStr | A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study |
| title_full_unstemmed | A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study |
| title_short | A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study |
| title_sort | systematic review of the risk factors for clinical response to opioids for all age patients with cancer related pain and presentation of the paediatric stop pain study |
| topic | Cancer pain Children Opioid efficacy Opioid safety |
| url | http://link.springer.com/article/10.1186/s12885-018-4478-3 |
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