Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti
Abstract This study describes the evolution of knockdown resistance (kdr) haplotypes in Aedes aegypti in response to pyrethroid insecticide use over the course of 18 years in Iquitos, Peru. Based on the duration and intensiveness of sampling (~10,000 samples), this is the most thorough study of kdr...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Evolutionary Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/eva.13269 |
| _version_ | 1819017903189524480 |
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| author | Jennifer Baltzegar Michael Vella Christian Gunning Gissella Vasquez Helvio Astete Fred Stell Michael Fisher Thomas W. Scott Audrey Lenhart Alun L. Lloyd Amy Morrison Fred Gould |
| author_facet | Jennifer Baltzegar Michael Vella Christian Gunning Gissella Vasquez Helvio Astete Fred Stell Michael Fisher Thomas W. Scott Audrey Lenhart Alun L. Lloyd Amy Morrison Fred Gould |
| author_sort | Jennifer Baltzegar |
| collection | DOAJ |
| description | Abstract This study describes the evolution of knockdown resistance (kdr) haplotypes in Aedes aegypti in response to pyrethroid insecticide use over the course of 18 years in Iquitos, Peru. Based on the duration and intensiveness of sampling (~10,000 samples), this is the most thorough study of kdr population genetics in Ae. aegypti to date within a city. We provide evidence for the direct connection between programmatic citywide pyrethroid spraying and the increase in frequency of specific kdr haplotypes by identifying two evolutionary events in the population. The relatively high selection coefficients, even under infrequent insecticide pressure, emphasize how quickly Ae. aegypti populations can evolve. In our examination of the literature on mosquitoes and other insect pests, we could find no cases where a pest evolved so quickly to so few exposures to low or nonresidual insecticide applications. The observed rapid increase in frequency of resistance alleles might have been aided by the incomplete dominance of resistance‐conferring alleles over corresponding susceptibility alleles. In addition to dramatic temporal shifts, spatial suppression experiments reveal that genetic heterogeneity existed not only at the citywide scale, but also on a very fine scale within the city. |
| first_indexed | 2024-12-21T03:10:55Z |
| format | Article |
| id | doaj.art-8348fb87da254662845138957466426a |
| institution | Directory Open Access Journal |
| issn | 1752-4571 |
| language | English |
| last_indexed | 2024-12-21T03:10:55Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Evolutionary Applications |
| spelling | doaj.art-8348fb87da254662845138957466426a2022-12-21T19:17:59ZengWileyEvolutionary Applications1752-45712021-08-011482098211310.1111/eva.13269Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegyptiJennifer Baltzegar0Michael Vella1Christian Gunning2Gissella Vasquez3Helvio Astete4Fred Stell5Michael Fisher6Thomas W. Scott7Audrey Lenhart8Alun L. Lloyd9Amy Morrison10Fred Gould11Graduate Program in Genetics College of Sciences North Carolina State University Raleigh NC USAGenetic Engineering and Society Center North Carolina State University Raleigh NC USAOdum School of Ecology University of Georgia Athens GA USADepartment of Entomology U.S. Naval Medical Research Unit. No 6. Bellavista PeruDepartment of Entomology U.S. Naval Medical Research Unit. No 6. Bellavista PeruDepartment of Entomology U.S. Naval Medical Research Unit. No 6. Bellavista PeruDepartment of Entomology U.S. Naval Medical Research Unit. No 6. Bellavista PeruDepartment of Entomology and Nematology University of California Davis CA USADivision of Parasitic Diseases and Malaria Centers for Disease Control and Prevention Atlanta GA USAGenetic Engineering and Society Center North Carolina State University Raleigh NC USADepartment of Entomology U.S. Naval Medical Research Unit. No 6. Bellavista PeruGenetic Engineering and Society Center North Carolina State University Raleigh NC USAAbstract This study describes the evolution of knockdown resistance (kdr) haplotypes in Aedes aegypti in response to pyrethroid insecticide use over the course of 18 years in Iquitos, Peru. Based on the duration and intensiveness of sampling (~10,000 samples), this is the most thorough study of kdr population genetics in Ae. aegypti to date within a city. We provide evidence for the direct connection between programmatic citywide pyrethroid spraying and the increase in frequency of specific kdr haplotypes by identifying two evolutionary events in the population. The relatively high selection coefficients, even under infrequent insecticide pressure, emphasize how quickly Ae. aegypti populations can evolve. In our examination of the literature on mosquitoes and other insect pests, we could find no cases where a pest evolved so quickly to so few exposures to low or nonresidual insecticide applications. The observed rapid increase in frequency of resistance alleles might have been aided by the incomplete dominance of resistance‐conferring alleles over corresponding susceptibility alleles. In addition to dramatic temporal shifts, spatial suppression experiments reveal that genetic heterogeneity existed not only at the citywide scale, but also on a very fine scale within the city.https://doi.org/10.1111/eva.13269Aedes aegyptidominanceinsecticide resistancekdrknockdown resistanceselection |
| spellingShingle | Jennifer Baltzegar Michael Vella Christian Gunning Gissella Vasquez Helvio Astete Fred Stell Michael Fisher Thomas W. Scott Audrey Lenhart Alun L. Lloyd Amy Morrison Fred Gould Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti Evolutionary Applications Aedes aegypti dominance insecticide resistance kdr knockdown resistance selection |
| title | Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti |
| title_full | Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti |
| title_fullStr | Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti |
| title_full_unstemmed | Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti |
| title_short | Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti |
| title_sort | rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in aedes aegypti |
| topic | Aedes aegypti dominance insecticide resistance kdr knockdown resistance selection |
| url | https://doi.org/10.1111/eva.13269 |
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