Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole
Fluconazole is one of the triazole antifungal agent for Candida albican. For comparison of single versus sequential dose of fluconazole, a double-blind randomized clinical trial was counducted on 80 married 20-45 years old women who had chronic vaginal candidiasis. The patients randomized into two g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2003-09-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-104&slc_lang=en&sid=1 |
| _version_ | 1818139521829568512 |
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| author | Farahnaz Kamali Tayebeh Gharibi Behrooz Naiemi Poorandokht Afshary |
| author_facet | Farahnaz Kamali Tayebeh Gharibi Behrooz Naiemi Poorandokht Afshary |
| author_sort | Farahnaz Kamali |
| collection | DOAJ |
| description | Fluconazole is one of the triazole antifungal agent for Candida albican. For comparison of single versus sequential dose of fluconazole, a double-blind randomized clinical trial was counducted on 80 married 20-45 years old women who had chronic vaginal candidiasis. The patients randomized into two groups, 40 patients received two ( zero and 72 hours ) doses of fluconazole and the other group received one 150 mg dose of the drug at zero and placebo at 72 hours later. The patients were examined at 2 & 6 weeks after treatment. The groups showed decreased signs and symptoms of vaginal candidiasis during examination periods, however there was no significant difference between groups (p>0.05). Wet mount & culture were negative in the 2nd week in two groups but at the 6th week after treatment, 95.3% and 72.5% of patients in control and case groups, respectively had negative results (p<0.05). Therefore, single and sequential doses of fluconazole have the same result for treatment of vaginal candidiasis but sequential dose reduces the relapse rate of the disease. |
| first_indexed | 2024-12-11T10:29:25Z |
| format | Article |
| id | doaj.art-834b1e5ae8df415bbdced505fac52805 |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-11T10:29:25Z |
| publishDate | 2003-09-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-834b1e5ae8df415bbdced505fac528052022-12-22T01:11:00ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542003-09-01612530Treatment of candida vaginitis: comparison of single and sequential dose of fluconazoleFarahnaz Kamali0Tayebeh Gharibi1Behrooz Naiemi2Poorandokht Afshary3 Fluconazole is one of the triazole antifungal agent for Candida albican. For comparison of single versus sequential dose of fluconazole, a double-blind randomized clinical trial was counducted on 80 married 20-45 years old women who had chronic vaginal candidiasis. The patients randomized into two groups, 40 patients received two ( zero and 72 hours ) doses of fluconazole and the other group received one 150 mg dose of the drug at zero and placebo at 72 hours later. The patients were examined at 2 & 6 weeks after treatment. The groups showed decreased signs and symptoms of vaginal candidiasis during examination periods, however there was no significant difference between groups (p>0.05). Wet mount & culture were negative in the 2nd week in two groups but at the 6th week after treatment, 95.3% and 72.5% of patients in control and case groups, respectively had negative results (p<0.05). Therefore, single and sequential doses of fluconazole have the same result for treatment of vaginal candidiasis but sequential dose reduces the relapse rate of the disease.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-104&slc_lang=en&sid=1fluconazole vaginitis candidiasis fungal |
| spellingShingle | Farahnaz Kamali Tayebeh Gharibi Behrooz Naiemi Poorandokht Afshary Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole Iranian South Medical Journal fluconazole vaginitis candidiasis fungal |
| title | Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole |
| title_full | Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole |
| title_fullStr | Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole |
| title_full_unstemmed | Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole |
| title_short | Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole |
| title_sort | treatment of candida vaginitis comparison of single and sequential dose of fluconazole |
| topic | fluconazole vaginitis candidiasis fungal |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-104&slc_lang=en&sid=1 |
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