Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells

Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells

Aberrant activation of hepatocyte growth factor (HGF) and its receptor c-Met axis promotes tumor growth. Therefore, many clinical trials have been conducted. A phase 3 trial investigating a monoclonal antibody targeting HGF in combination with fluoropyrimidine-based chemotherapy had to be terminated...

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Bibliographic Details
Main Authors: Manabu Okumura, Tomomi Iwakiri, Naoki Yoshikawa, Takao Nagatomo, Takanori Ayabe, Isao Tsuneyoshi, Ryuji Ikeda
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocyte growth factor
HGF
5-FU
UPP1
c-Met
erlotinib
Online Access:https://www.mdpi.com/1422-0067/23/16/9108

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