The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection
Abstract Background Helicobacter pylori (H. pylori) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors influence the development and healing of peptic ulcers. This study aimed to evaluate the ratios of matrix meta...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-02923-z |
| _version_ | 1797559340135088128 |
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| author | Mohammad Negaresh Elham Safarzadeh Nasrin Fouladi Somaieh Matin Sanaz Pourfarzi |
| author_facet | Mohammad Negaresh Elham Safarzadeh Nasrin Fouladi Somaieh Matin Sanaz Pourfarzi |
| author_sort | Mohammad Negaresh |
| collection | DOAJ |
| description | Abstract Background Helicobacter pylori (H. pylori) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors influence the development and healing of peptic ulcers. This study aimed to evaluate the ratios of matrix metalloproteinase-2 (MMP-2) to tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with peptic ulcers that are sensitive or resistant to H. pylori treatment and compare them with healthy individuals. Methods In this study, 95 patients were included and divided into two groups sensitive (41 patients) and resistant to treatment (54 patients). The results were compared with a control group of 20 participants with normal endoscopy and H. pylori-negative. After obtaining written informed consent, five ml of venous blood was taken to determine their serum MMP-2 and TIMP-1 levels using an enzyme-linked immunosorbent assay. Results In patients with H. pylori-induced peptic ulcers, the MMP-2/TIMP-1 ratio was significantly higher than the healthy controls (P < 0.05). MMP-2 level was associated with patients’ response to treatment (P < 0.05). The MMP-2/TIMP-1 ratio was higher in patients with simultaneous gastric and duodenal ulcers (P < 0.05). Conclusion It seems that peptic ulcer disease caused by infection with H. pylori increases the MMP-2/TIMP-1 ratio in patients with peptic ulcers. However, it might not be a good predictor of refractory H. pylori-induced peptic ulcer disease. |
| first_indexed | 2024-03-10T17:43:51Z |
| format | Article |
| id | doaj.art-834cb3b56f6d489e88da1da244e6ab04 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-10T17:43:51Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-834cb3b56f6d489e88da1da244e6ab042023-11-20T09:36:00ZengBMCBMC Gastroenterology1471-230X2023-08-012311810.1186/s12876-023-02923-zThe evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infectionMohammad Negaresh0Elham Safarzadeh1Nasrin Fouladi2Somaieh Matin3Sanaz Pourfarzi4Department of Internal Medicine, Faculty of Medicine, Ardabil University of Medical SciencesSchool of Medicine and Allied Medical Sciences, Ardabil University of Medical SciencesSocial Determinants of Health Research Center, Ardabil University of Medical SciencesGastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Digestive Diseases Research Center, Ardabil University of Medical SciencesStudents Research Committee, School of Medicine, Ardabil University of Medical SciencesAbstract Background Helicobacter pylori (H. pylori) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors influence the development and healing of peptic ulcers. This study aimed to evaluate the ratios of matrix metalloproteinase-2 (MMP-2) to tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with peptic ulcers that are sensitive or resistant to H. pylori treatment and compare them with healthy individuals. Methods In this study, 95 patients were included and divided into two groups sensitive (41 patients) and resistant to treatment (54 patients). The results were compared with a control group of 20 participants with normal endoscopy and H. pylori-negative. After obtaining written informed consent, five ml of venous blood was taken to determine their serum MMP-2 and TIMP-1 levels using an enzyme-linked immunosorbent assay. Results In patients with H. pylori-induced peptic ulcers, the MMP-2/TIMP-1 ratio was significantly higher than the healthy controls (P < 0.05). MMP-2 level was associated with patients’ response to treatment (P < 0.05). The MMP-2/TIMP-1 ratio was higher in patients with simultaneous gastric and duodenal ulcers (P < 0.05). Conclusion It seems that peptic ulcer disease caused by infection with H. pylori increases the MMP-2/TIMP-1 ratio in patients with peptic ulcers. However, it might not be a good predictor of refractory H. pylori-induced peptic ulcer disease.https://doi.org/10.1186/s12876-023-02923-zMMP-2TIMP-1Peptic ulcerHelicobacter pylori infection |
| spellingShingle | Mohammad Negaresh Elham Safarzadeh Nasrin Fouladi Somaieh Matin Sanaz Pourfarzi The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection BMC Gastroenterology MMP-2 TIMP-1 Peptic ulcer Helicobacter pylori infection |
| title | The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection |
| title_full | The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection |
| title_fullStr | The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection |
| title_full_unstemmed | The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection |
| title_short | The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection |
| title_sort | evaluation of the mmp 2 timp 1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection |
| topic | MMP-2 TIMP-1 Peptic ulcer Helicobacter pylori infection |
| url | https://doi.org/10.1186/s12876-023-02923-z |
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