Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery
Porifera, commonly referred to as marine sponges, are acknowledged as major producers of marine natural products (MNPs). Sponges of the genus <i>Phorbas</i> have attracted much attention over the years. They are widespread in all continents, and several structurally unique compounds have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/12/667 |
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| author | Alessia Caso Fernanda Barbosa da Silva Germana Esposito Roberta Teta Gerardo Della Sala Laura P. A. Nunes Cavalcanti Alessandra Leda Valverde Roberto Carlos C. Martins Valeria Costantino |
| author_facet | Alessia Caso Fernanda Barbosa da Silva Germana Esposito Roberta Teta Gerardo Della Sala Laura P. A. Nunes Cavalcanti Alessandra Leda Valverde Roberto Carlos C. Martins Valeria Costantino |
| author_sort | Alessia Caso |
| collection | DOAJ |
| description | Porifera, commonly referred to as marine sponges, are acknowledged as major producers of marine natural products (MNPs). Sponges of the genus <i>Phorbas</i> have attracted much attention over the years. They are widespread in all continents, and several structurally unique compounds have been identified from this species. Terpenes, mainly sesterterpenoids, are the major secondary metabolites isolated from <i>Phorbas</i> species, even though several alkaloids and steroids have also been reported. Many of these compounds have presented interesting biological activities. Particularly, <i>Phorbas</i> sponges have been demonstrated to be a source of cytotoxic metabolites. In addition, MNPs exhibiting cytostatic, antimicrobial, and anti-inflammatory activities have been isolated and structurally characterized. This review provides an overview of almost 130 secondary metabolites from <i>Phorbas</i> sponges and their biological activities, and it covers the literature since the first study published in 1993 until November 2021, including approximately 60 records. The synthetic routes to the most interesting compounds are briefly outlined. |
| first_indexed | 2024-03-10T03:41:09Z |
| format | Article |
| id | doaj.art-834d0b8d133146e8811b0f25ee7fdbae |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T03:41:09Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-834d0b8d133146e8811b0f25ee7fdbae2023-11-23T09:17:58ZengMDPI AGMarine Drugs1660-33972021-11-01191266710.3390/md19120667Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug DiscoveryAlessia Caso0Fernanda Barbosa da Silva1Germana Esposito2Roberta Teta3Gerardo Della Sala4Laura P. A. Nunes Cavalcanti5Alessandra Leda Valverde6Roberto Carlos C. Martins7Valeria Costantino8Department of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, ItalyInstituto de Química de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Rio de Janeiro 21941-599, BrazilDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, ItalyDepartment of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80125 Naples, ItalyInstituto de Química de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Rio de Janeiro 21941-599, BrazilDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/n, Niterói, Rio de Janeiro 24020-141, BrazilInstituto de Química de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Rio de Janeiro 21941-599, BrazilDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, ItalyPorifera, commonly referred to as marine sponges, are acknowledged as major producers of marine natural products (MNPs). Sponges of the genus <i>Phorbas</i> have attracted much attention over the years. They are widespread in all continents, and several structurally unique compounds have been identified from this species. Terpenes, mainly sesterterpenoids, are the major secondary metabolites isolated from <i>Phorbas</i> species, even though several alkaloids and steroids have also been reported. Many of these compounds have presented interesting biological activities. Particularly, <i>Phorbas</i> sponges have been demonstrated to be a source of cytotoxic metabolites. In addition, MNPs exhibiting cytostatic, antimicrobial, and anti-inflammatory activities have been isolated and structurally characterized. This review provides an overview of almost 130 secondary metabolites from <i>Phorbas</i> sponges and their biological activities, and it covers the literature since the first study published in 1993 until November 2021, including approximately 60 records. The synthetic routes to the most interesting compounds are briefly outlined.https://www.mdpi.com/1660-3397/19/12/667<i>Phorbas</i>marine spongesmarine natural products (MNPs)alkaloidsterpenoidsmacrolides |
| spellingShingle | Alessia Caso Fernanda Barbosa da Silva Germana Esposito Roberta Teta Gerardo Della Sala Laura P. A. Nunes Cavalcanti Alessandra Leda Valverde Roberto Carlos C. Martins Valeria Costantino Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery Marine Drugs <i>Phorbas</i> marine sponges marine natural products (MNPs) alkaloids terpenoids macrolides |
| title | Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery |
| title_full | Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery |
| title_fullStr | Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery |
| title_full_unstemmed | Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery |
| title_short | Exploring Chemical Diversity of <i>Phorbas</i> Sponges as a Source of Novel Lead Compounds in Drug Discovery |
| title_sort | exploring chemical diversity of i phorbas i sponges as a source of novel lead compounds in drug discovery |
| topic | <i>Phorbas</i> marine sponges marine natural products (MNPs) alkaloids terpenoids macrolides |
| url | https://www.mdpi.com/1660-3397/19/12/667 |
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