Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease
Background: Nonadherence to medication is a common and serious issue in the treatment of patients with Parkinson's disease (PD). Among others, distinct nonmotor symptoms (NMS) were found to be associated with nonadherence in PD. Here, we aimed to confirm the association between NMS and adherenc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.551696/full |
| _version_ | 1828851305844572160 |
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| author | Sarah Mendorf Otto W. Witte Otto W. Witte Hannah Zipprich Hannah Zipprich Tino Prell Tino Prell |
| author_facet | Sarah Mendorf Otto W. Witte Otto W. Witte Hannah Zipprich Hannah Zipprich Tino Prell Tino Prell |
| author_sort | Sarah Mendorf |
| collection | DOAJ |
| description | Background: Nonadherence to medication is a common and serious issue in the treatment of patients with Parkinson's disease (PD). Among others, distinct nonmotor symptoms (NMS) were found to be associated with nonadherence in PD. Here, we aimed to confirm the association between NMS and adherence.Methods: In this observational study, the following data were collected: sociodemographic data, the German versions of the Movement Disorder Society-sponsored revision of the unified Parkinson's disease rating scale for motor function (MDS-UPDRS III), Hoehn and Yahr (H&Y) stage, levodopa equivalent daily dose (LEDD), Becks depression inventory II (BDI-II), nonmotor symptoms questionnaire (NMSQ), and the Stendal adherence to medication score (SAMS).Results: The final sample included 137 people with PD [54 (39.4%) females] with a mean age of 71.3 ± 8.2 years. According to SAMS, 10.9% of the patients were fully adherent, 73% were moderately nonadherent, and 16.1% showed clinically significant nonadherence. Nonadherence was associated with LEDD, BDI-II, education level, MDS-UPDRS III, and the NMSQ. The number of NMS was higher in nonadherent patients than in adherent patients. In the multiple stepwise regression analysis, the items 5 (constipation), 17 (anxiety), and 21 (falls) predicted nonadherence to medication. These NMSQ items also remained significant predictors for SAMS after correction for LEDD, MDS-UPDRS III, BDI-II, age, education level, gender, and disease duration.Conclusion: Our study, in principle, confirms the association between NMS burden and nonadherence in PD. However, in contrast to other clinical factors, the relevance of NMSQ in terms of nonadherence is low. More studies with larger sample sizes are necessary to explore the impact of distinct NMS on adherence. |
| first_indexed | 2024-12-12T23:29:16Z |
| format | Article |
| id | doaj.art-834d8c631e3a4e38a62d1b71fb772ace |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T23:29:16Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-834d8c631e3a4e38a62d1b71fb772ace2022-12-22T00:07:52ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-10-011110.3389/fneur.2020.551696551696Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's DiseaseSarah Mendorf0Otto W. Witte1Otto W. Witte2Hannah Zipprich3Hannah Zipprich4Tino Prell5Tino Prell6Department of Neurology, Jena University Hospital, Jena, GermanyDepartment of Neurology, Jena University Hospital, Jena, GermanyCentre for Healthy Ageing, Jena University Hospital, Jena, GermanyDepartment of Neurology, Jena University Hospital, Jena, GermanyCentre for Healthy Ageing, Jena University Hospital, Jena, GermanyDepartment of Neurology, Jena University Hospital, Jena, GermanyCentre for Healthy Ageing, Jena University Hospital, Jena, GermanyBackground: Nonadherence to medication is a common and serious issue in the treatment of patients with Parkinson's disease (PD). Among others, distinct nonmotor symptoms (NMS) were found to be associated with nonadherence in PD. Here, we aimed to confirm the association between NMS and adherence.Methods: In this observational study, the following data were collected: sociodemographic data, the German versions of the Movement Disorder Society-sponsored revision of the unified Parkinson's disease rating scale for motor function (MDS-UPDRS III), Hoehn and Yahr (H&Y) stage, levodopa equivalent daily dose (LEDD), Becks depression inventory II (BDI-II), nonmotor symptoms questionnaire (NMSQ), and the Stendal adherence to medication score (SAMS).Results: The final sample included 137 people with PD [54 (39.4%) females] with a mean age of 71.3 ± 8.2 years. According to SAMS, 10.9% of the patients were fully adherent, 73% were moderately nonadherent, and 16.1% showed clinically significant nonadherence. Nonadherence was associated with LEDD, BDI-II, education level, MDS-UPDRS III, and the NMSQ. The number of NMS was higher in nonadherent patients than in adherent patients. In the multiple stepwise regression analysis, the items 5 (constipation), 17 (anxiety), and 21 (falls) predicted nonadherence to medication. These NMSQ items also remained significant predictors for SAMS after correction for LEDD, MDS-UPDRS III, BDI-II, age, education level, gender, and disease duration.Conclusion: Our study, in principle, confirms the association between NMS burden and nonadherence in PD. However, in contrast to other clinical factors, the relevance of NMSQ in terms of nonadherence is low. More studies with larger sample sizes are necessary to explore the impact of distinct NMS on adherence.https://www.frontiersin.org/article/10.3389/fneur.2020.551696/fulladherenceantiparkinson drugsnon-motor symptomanxietydepression |
| spellingShingle | Sarah Mendorf Otto W. Witte Otto W. Witte Hannah Zipprich Hannah Zipprich Tino Prell Tino Prell Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease Frontiers in Neurology adherence antiparkinson drugs non-motor symptom anxiety depression |
| title | Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease |
| title_full | Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease |
| title_fullStr | Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease |
| title_full_unstemmed | Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease |
| title_short | Association Between Nonmotor Symptoms and Nonadherence to Medication in Parkinson's Disease |
| title_sort | association between nonmotor symptoms and nonadherence to medication in parkinson s disease |
| topic | adherence antiparkinson drugs non-motor symptom anxiety depression |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.551696/full |
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