Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape
Background25-hydroxyvitamin D [25(OH)D], the major form of vitamin D in the body, has a non-linear association with stroke risk. However, the association is not fully understood. The specific shape of the association and the ideal value of 25(OH)D related to minimum risk of stroke remain unclear.Aim...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1050788/full |
| _version_ | 1828071096519229440 |
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| author | Jue-heng Pan Shuo-long Wu Jing-xiang Ma Long Chang Ying-feng Zheng Xiao-dong Wang Xiao-dong Wang |
| author_facet | Jue-heng Pan Shuo-long Wu Jing-xiang Ma Long Chang Ying-feng Zheng Xiao-dong Wang Xiao-dong Wang |
| author_sort | Jue-heng Pan |
| collection | DOAJ |
| description | Background25-hydroxyvitamin D [25(OH)D], the major form of vitamin D in the body, has a non-linear association with stroke risk. However, the association is not fully understood. The specific shape of the association and the ideal value of 25(OH)D related to minimum risk of stroke remain unclear.AimWe conducted the study to establish the correlation between circulating 25(OH)D and stroke history and determine the ideal value of 25(OH)D in relation to the lowest stroke prevalence.MethodsData from the National Health and Nutrition Examination Survey (NHANES) were used for analyzes. We used multivariate logistic regression analysis with fitted smooth curves to explore the relationship between 25(OH)D and self-reported stroke history. Subsequently, 40,632 participants were enrolled in the study.ResultsA reverse J-shaped association between 25(OH)D and stroke history was determined, where the lowest stroke prevalence for the 25(OH)D level was about 60 nmol/L. After adjusting for confounding factors, prevalence of stroke showed an increasing trend below and above the middle quintile (53.2–65.4 nmol/L) of 25(OH)D. Participants with 25(OH)D levels in the lowest quintile (≤ 39.3 nmol/L) had a 38% increased prevalence of stroke (OR 1.38, 95 %CI 1.12–1.70), while those in the higher level range of 25(OH)D (65.5–80.8 nmol/L) had a 27% higher stroke prevalence (OR 1.27, 95 %CI 1.03–1.57).ConclusionUsing data from a large, cross-sectional cohort program, we found that circulating 25(OH)D was related to stroke history in a reverse J-shaped manner. Given how the causal relationship between circulating 25(OH)D and history of stroke has not been established, more high-quality evidence based on the reverse J-shaped feature is needed to elucidate the link between vitamin D and stroke risk, and the effect of vitamin D supplements on stroke prevention. |
| first_indexed | 2024-04-11T00:49:07Z |
| format | Article |
| id | doaj.art-834e1c3d9764432f929ec4a775a311a3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T00:49:07Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-834e1c3d9764432f929ec4a775a311a32023-01-05T11:56:47ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10507881050788Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shapeJue-heng Pan0Shuo-long Wu1Jing-xiang Ma2Long Chang3Ying-feng Zheng4Xiao-dong Wang5Xiao-dong Wang6Department of Neurosurgery, Affiliated Shunde Hospital, Ji'nan University, Foshan, ChinaDepartment of Neurosurgery, Affiliated Shunde Hospital, Ji'nan University, Foshan, ChinaDepartment of Neurosurgery, Affiliated Shunde Hospital, Ji'nan University, Foshan, ChinaDepartment of Neurosurgery, Affiliated Shunde Hospital, Ji'nan University, Foshan, ChinaDepartment of Neurosurgery, Affiliated Shunde Hospital, Ji'nan University, Foshan, ChinaDepartment of Neurosurgery, Affiliated Shunde Hospital, Ji'nan University, Foshan, ChinaDepartment of Neurosurgery, The First Affiliated Hospital, Ji'nan University, Guangzhou, ChinaBackground25-hydroxyvitamin D [25(OH)D], the major form of vitamin D in the body, has a non-linear association with stroke risk. However, the association is not fully understood. The specific shape of the association and the ideal value of 25(OH)D related to minimum risk of stroke remain unclear.AimWe conducted the study to establish the correlation between circulating 25(OH)D and stroke history and determine the ideal value of 25(OH)D in relation to the lowest stroke prevalence.MethodsData from the National Health and Nutrition Examination Survey (NHANES) were used for analyzes. We used multivariate logistic regression analysis with fitted smooth curves to explore the relationship between 25(OH)D and self-reported stroke history. Subsequently, 40,632 participants were enrolled in the study.ResultsA reverse J-shaped association between 25(OH)D and stroke history was determined, where the lowest stroke prevalence for the 25(OH)D level was about 60 nmol/L. After adjusting for confounding factors, prevalence of stroke showed an increasing trend below and above the middle quintile (53.2–65.4 nmol/L) of 25(OH)D. Participants with 25(OH)D levels in the lowest quintile (≤ 39.3 nmol/L) had a 38% increased prevalence of stroke (OR 1.38, 95 %CI 1.12–1.70), while those in the higher level range of 25(OH)D (65.5–80.8 nmol/L) had a 27% higher stroke prevalence (OR 1.27, 95 %CI 1.03–1.57).ConclusionUsing data from a large, cross-sectional cohort program, we found that circulating 25(OH)D was related to stroke history in a reverse J-shaped manner. Given how the causal relationship between circulating 25(OH)D and history of stroke has not been established, more high-quality evidence based on the reverse J-shaped feature is needed to elucidate the link between vitamin D and stroke risk, and the effect of vitamin D supplements on stroke prevention.https://www.frontiersin.org/articles/10.3389/fneur.2022.1050788/fullstrokevitamin D25-hydroxyvitaminstroke preventioncross-sectionalNHANES |
| spellingShingle | Jue-heng Pan Shuo-long Wu Jing-xiang Ma Long Chang Ying-feng Zheng Xiao-dong Wang Xiao-dong Wang Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape Frontiers in Neurology stroke vitamin D 25-hydroxyvitamin stroke prevention cross-sectional NHANES |
| title | Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape |
| title_full | Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape |
| title_fullStr | Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape |
| title_full_unstemmed | Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape |
| title_short | Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape |
| title_sort | serum 25 hydroxyvitamin d is associated with stroke history in a reverse j shape |
| topic | stroke vitamin D 25-hydroxyvitamin stroke prevention cross-sectional NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1050788/full |
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