Updates on Biodegradable Formulations for Ocular Drug Delivery
The complex nature of the ocular drug delivery barrier presents a significant challenge to the effective administration of drugs, resulting in poor therapeutic outcomes. To address this issue, it is essential to investigate new drugs and alternative delivery routes and vehicles. One promising approa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/3/734 |
| _version_ | 1797609575957921792 |
|---|---|
| author | Ta-Hsin Tsung Yi-Hao Chen Da-Wen Lu |
| author_facet | Ta-Hsin Tsung Yi-Hao Chen Da-Wen Lu |
| author_sort | Ta-Hsin Tsung |
| collection | DOAJ |
| description | The complex nature of the ocular drug delivery barrier presents a significant challenge to the effective administration of drugs, resulting in poor therapeutic outcomes. To address this issue, it is essential to investigate new drugs and alternative delivery routes and vehicles. One promising approach is the use of biodegradable formulations to develop potential ocular drug delivery technologies. These include hydrogels, biodegradable microneedles, implants, and polymeric nanocarriers such as liposomes, nanoparticles, nanosuspensions, nanomicelles, and nanoemulsions. The research in these areas is rapidly growing. In this review, we provide an overview of recent updates in biodegradable formulations for ocular drug delivery over the past decade. Additionally, we examine the clinical use of different biodegradable formulations in various ocular diseases. The aim of this review is to gain a deeper understanding of potential future trends in biodegradable ocular drug delivery systems and to raise awareness of their potential for practical clinical application as a means of providing new treatment options for ocular diseases. |
| first_indexed | 2024-03-11T06:02:19Z |
| format | Article |
| id | doaj.art-834fe9832eae41dba49181702b83109d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:19Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-834fe9832eae41dba49181702b83109d2023-11-17T13:13:38ZengMDPI AGPharmaceutics1999-49232023-02-0115373410.3390/pharmaceutics15030734Updates on Biodegradable Formulations for Ocular Drug DeliveryTa-Hsin Tsung0Yi-Hao Chen1Da-Wen Lu2Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, TaiwanDepartment of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, TaiwanDepartment of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, TaiwanThe complex nature of the ocular drug delivery barrier presents a significant challenge to the effective administration of drugs, resulting in poor therapeutic outcomes. To address this issue, it is essential to investigate new drugs and alternative delivery routes and vehicles. One promising approach is the use of biodegradable formulations to develop potential ocular drug delivery technologies. These include hydrogels, biodegradable microneedles, implants, and polymeric nanocarriers such as liposomes, nanoparticles, nanosuspensions, nanomicelles, and nanoemulsions. The research in these areas is rapidly growing. In this review, we provide an overview of recent updates in biodegradable formulations for ocular drug delivery over the past decade. Additionally, we examine the clinical use of different biodegradable formulations in various ocular diseases. The aim of this review is to gain a deeper understanding of potential future trends in biodegradable ocular drug delivery systems and to raise awareness of their potential for practical clinical application as a means of providing new treatment options for ocular diseases.https://www.mdpi.com/1999-4923/15/3/734biodegradable drug deliveryocular drug deliverybiodegradable polymersnanoparticle drug deliverypolymeric micellesliposomes |
| spellingShingle | Ta-Hsin Tsung Yi-Hao Chen Da-Wen Lu Updates on Biodegradable Formulations for Ocular Drug Delivery Pharmaceutics biodegradable drug delivery ocular drug delivery biodegradable polymers nanoparticle drug delivery polymeric micelles liposomes |
| title | Updates on Biodegradable Formulations for Ocular Drug Delivery |
| title_full | Updates on Biodegradable Formulations for Ocular Drug Delivery |
| title_fullStr | Updates on Biodegradable Formulations for Ocular Drug Delivery |
| title_full_unstemmed | Updates on Biodegradable Formulations for Ocular Drug Delivery |
| title_short | Updates on Biodegradable Formulations for Ocular Drug Delivery |
| title_sort | updates on biodegradable formulations for ocular drug delivery |
| topic | biodegradable drug delivery ocular drug delivery biodegradable polymers nanoparticle drug delivery polymeric micelles liposomes |
| url | https://www.mdpi.com/1999-4923/15/3/734 |
| work_keys_str_mv | AT tahsintsung updatesonbiodegradableformulationsforoculardrugdelivery AT yihaochen updatesonbiodegradableformulationsforoculardrugdelivery AT dawenlu updatesonbiodegradableformulationsforoculardrugdelivery |