Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo–YAP1 pathway

Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo–YAP1 pathway

Abstract Background Helicobacter pylori (H. pylori) infection causes aberrant DNA methylation and contributes to the risk of gastric cancer (GC). Guanine nucleotide-binding protein subunit beta-4 (GNB4) is involved in various tumorigenic processes. We found an aberrant methylation level of GNB4 in H...

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Bibliographic Details
Main Authors: Duanrui Liu, Yunyun Liu, Wenshuai Zhu, Yi Lu, Jingyu Zhu, Xiaoli Ma, Yuanxin Xing, Mingjie Yuan, Bin Ning, Yunshan Wang, Yanfei Jia
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Medicine
Subjects:
Gastric cancer
Helicobacter pylori
TET1
DNA demethylation
Hippo–YAP1 pathway
Online Access:https://doi.org/10.1186/s12916-023-02842-6

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