The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes
Pseudomonas aeruginosa is an opportunistic pathogen that causes a multitude of infections. These infections can occur at almost any site in the body and are usually associated with a breach of the innate immune system. One of the prominent sites where P. aeruginosa causes chronic infections is withi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00082/full |
| _version_ | 1828771476979843072 |
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| author | Michael J Schurr Yuta eOkkotsu Alexander S Little |
| author_facet | Michael J Schurr Yuta eOkkotsu Alexander S Little |
| author_sort | Michael J Schurr |
| collection | DOAJ |
| description | Pseudomonas aeruginosa is an opportunistic pathogen that causes a multitude of infections. These infections can occur at almost any site in the body and are usually associated with a breach of the innate immune system. One of the prominent sites where P. aeruginosa causes chronic infections is within the lungs of cystic fibrosis patients. P. aeruginosa uses two-component systems that sense environmental changes to differentially express virulence factors that cause both acute and chronic infections. The P. aeruginosa AlgZR two component system is one of its global regulatory systems that affects the organism’s fitness in a broad manner. This two-component system is absolutely required for two P. aeruginosa phenotypes: twitching motility and alginate production, indicating its importance in both chronic and acute infections. Additionally, global transcriptome analyses indicate that it regulates the expression of many different genes, including those associated with quorum sensing, type IV pili, type III secretion system, anaerobic metabolism, cyanide and rhamnolipid production. This review examines the complex AlgZR regulatory network, what is known about the structure and function of each protein, and how it relates to the organism’s ability to cause infections. |
| first_indexed | 2024-12-11T14:25:53Z |
| format | Article |
| id | doaj.art-835244cbf7594f76bbd3d8dece093296 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T14:25:53Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-835244cbf7594f76bbd3d8dece0932962022-12-22T01:02:41ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882014-06-01410.3389/fcimb.2014.0008292968The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple PhenotypesMichael J Schurr0Yuta eOkkotsu1Alexander S Little2University of ColoradoUniversity of ColoradoUniversity of ColoradoPseudomonas aeruginosa is an opportunistic pathogen that causes a multitude of infections. These infections can occur at almost any site in the body and are usually associated with a breach of the innate immune system. One of the prominent sites where P. aeruginosa causes chronic infections is within the lungs of cystic fibrosis patients. P. aeruginosa uses two-component systems that sense environmental changes to differentially express virulence factors that cause both acute and chronic infections. The P. aeruginosa AlgZR two component system is one of its global regulatory systems that affects the organism’s fitness in a broad manner. This two-component system is absolutely required for two P. aeruginosa phenotypes: twitching motility and alginate production, indicating its importance in both chronic and acute infections. Additionally, global transcriptome analyses indicate that it regulates the expression of many different genes, including those associated with quorum sensing, type IV pili, type III secretion system, anaerobic metabolism, cyanide and rhamnolipid production. This review examines the complex AlgZR regulatory network, what is known about the structure and function of each protein, and how it relates to the organism’s ability to cause infections.http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00082/fullPseudomonas aeruginosaAlginateTwo-component regulationAlgZRtwitching motilityLytTR family |
| spellingShingle | Michael J Schurr Yuta eOkkotsu Alexander S Little The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes Frontiers in Cellular and Infection Microbiology Pseudomonas aeruginosa Alginate Two-component regulation AlgZR twitching motility LytTR family |
| title | The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes |
| title_full | The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes |
| title_fullStr | The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes |
| title_full_unstemmed | The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes |
| title_short | The Pseudomonas aeruginosa AlgZR Two-Component System Coordinates Multiple Phenotypes |
| title_sort | pseudomonas aeruginosa algzr two component system coordinates multiple phenotypes |
| topic | Pseudomonas aeruginosa Alginate Two-component regulation AlgZR twitching motility LytTR family |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00082/full |
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