Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Although closely related, these enzymes display very different substrate specificities that only partially overlap. This...

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Bibliographic Details
Main Authors: Terrone L. Rosenberry, Xavier Brazzolotto, Ian R. Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nachon
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
acetylcholinesterase
butyrylcholinesterase
crystal structure
kinetics
isothermal titration calorimetry
Online Access:https://www.mdpi.com/1420-3049/22/12/2098

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